Assay Detail
Binding
CHEMBL1031294
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Inhibition of Aurora-A by coupled assay
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
The discovery of the potent aurora inhibitor MK-0457 (VX-680).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 43 | 8.23 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 9.22 |
| CHEMBL564941 | — | — | 1 | 9.00 |
| CHEMBL559900 | — | — | 1 | 9.00 |
| CHEMBL484006 | — | — | 1 | 8.89 |
| CHEMBL484609 | — | — | 1 | 8.80 |
| CHEMBL484951 | — | — | 1 | 8.80 |
| CHEMBL482778 | — | — | 1 | 8.77 |
| CHEMBL551633 | — | — | 1 | 8.70 |
| CHEMBL552033 | — | — | 1 | 8.70 |
| CHEMBL552385 | — | — | 1 | 8.70 |
| CHEMBL563682 | — | — | 1 | 8.62 |
| CHEMBL557279 | — | — | 1 | 8.62 |
| CHEMBL564459 | — | — | 1 | 8.52 |
| CHEMBL482779 | — | — | 1 | 8.43 |
| CHEMBL557682 | — | — | 1 | 8.41 |
| CHEMBL561617 | — | — | 1 | 8.41 |
| CHEMBL484950 | — | — | 1 | 8.40 |
| CHEMBL562416 | — | — | 1 | 8.40 |
| CHEMBL561834 | — | — | 1 | 8.30 |
| CHEMBL562415 | — | — | 1 | 8.30 |
| CHEMBL560556 | — | — | 1 | 8.29 |
| CHEMBL562157 | — | — | 1 | 8.22 |
| CHEMBL556460 | — | — | 1 | 8.05 |
| CHEMBL552500 | — | — | 1 | 8.05 |
| CHEMBL565183 | — | — | 1 | 8.00 |
| CHEMBL564290 | — | — | 1 | 7.77 |
| CHEMBL550825 | — | — | 1 | 7.77 |
| CHEMBL562497 | — | — | 1 | 7.75 |
| CHEMBL549322 | — | — | 1 | 7.70 |
| CHEMBL560158 | — | — | 1 | 7.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL572878 | TOZASERTIB | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL564941 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL559900 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL484006 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL484609 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL484951 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL482778 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL551633 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL552033 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL552385 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL563682 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL557279 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL564459 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL482779 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL561617 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL557682 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL484950 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL562416 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL561834 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL562415 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL560556 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL562157 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL552500 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL556460 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL565183 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL564290 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL550825 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL562497 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL549322 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL560158 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL552038 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL551634 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL565205 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL359482 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL549536 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL549469 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL560630 | — | Ki | < | 3.0 | nM | - |
| CHEMBL554941 | — | Ki | < | 1.0 | nM | - |
| CHEMBL561421 | — | Ki | < | 1.0 | nM | - |
| CHEMBL564449 | — | Ki | < | 1.0 | nM | - |
| CHEMBL485351 | — | Ki | < | 1.0 | nM | - |
| CHEMBL485186 | — | Ki | < | 1.0 | nM | - |
| CHEMBL549668 | — | Ki | < | 1.0 | nM | - |