Compound Detail
CHEMBL485351
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Basic Information
| ChEMBL ID | CHEMBL485351 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SUIPNNKRHBDYHW-UHFFFAOYSA-N |
2
Targets
4
Activities
2
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
466.6
MW (Da)
3.89
ALogP
8
HBA
3
HBD
102.1
PSA (Ų)
0.43
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.62
Ki 1 meas. best 7.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| COLO 205 CHEMBL614561 | IC50 | 7.62 | 7.62 | 24.0 | 2 |
| Aurora kinase B CHEMBL2185 | IC50 | 7.6 | 7.6 | 25.0 | 1 |
| Aurora kinase B CHEMBL2185 | Ki | 7.6 | 7.6 | 25.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| COLO 205 | IC50 | = | 24.0 | nM | 7.62 | Antiproliferative activity against human COLO205 cells assessed as inhibition of... | 19320489 |
| COLO 205 | IC50 | = | 24.0 | nM | 7.62 | Antiproliferative activity against human COLO205 cells by [3H]thymidine uptake a... | 19447622 |
| Aurora kinase B | IC50 | = | 25.0 | nM | 7.6 | Inhibition of aurora B kinase | 19320489 |
| Aurora kinase B | Ki | = | 25.0 | nM | 7.6 | Inhibition of Aurora-B | 19447622 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19447622 | 10.1016/j.bmcl.2009.04.136 | COLO 205 | 2 |
| 19320489 | 10.1021/jm8012129 | Aurora kinase A | 1 |
| 19320489 | 10.1021/jm8012129 | Aurora kinase B | 1 |
| 19320489 | 10.1021/jm8012129 | COLO 205 | 1 |
| 19320489 | 10.1021/jm8012129 | No relevant target | 1 |
| 19447622 | 10.1016/j.bmcl.2009.04.136 | No relevant target | 1 |
| 19447622 | 10.1016/j.bmcl.2009.04.136 | Aurora kinase A | 1 |
| 19447622 | 10.1016/j.bmcl.2009.04.136 | Aurora kinase B | 1 |
Data from ChEMBL 36 via Core Engine