Assay Detail
Functional
CHEMBL981423
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Antiproliferative activity against human COLO205 cells assessed as inhibition of thymidine uptake after 96 hrs
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COLO 205 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and development of aurora kinase inhibitors as anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.07 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL484006 | — | — | 1 | 8.70 |
| CHEMBL484609 | — | — | 1 | 7.62 |
| CHEMBL485351 | — | — | 1 | 7.62 |
| CHEMBL485186 | — | — | 1 | 7.12 |
| CHEMBL482779 | — | — | 1 | 7.10 |
| CHEMBL482778 | — | — | 1 | 6.87 |
| CHEMBL484951 | — | — | 1 | 6.40 |
| CHEMBL484950 | — | — | 1 | 6.32 |
| CHEMBL359482 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL484006 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL484609 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL485351 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL485186 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL482779 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL482778 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL484951 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL484950 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL359482 | — | IC50 | = | 1400.0 | nM | 5.85 |