Assay Detail
Binding
CHEMBL1031295
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Inhibition of Aurora-B
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
The discovery of the potent aurora inhibitor MK-0457 (VX-680).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 38 | 7.12 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL484951 | — | — | 1 | 8.10 |
| CHEMBL485186 | — | — | 1 | 8.02 |
| CHEMBL484006 | — | — | 1 | 7.96 |
| CHEMBL482778 | — | — | 1 | 7.85 |
| CHEMBL561421 | — | — | 1 | 7.82 |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 7.75 |
| CHEMBL482779 | — | — | 1 | 7.75 |
| CHEMBL484609 | — | — | 1 | 7.70 |
| CHEMBL563682 | — | — | 1 | 7.64 |
| CHEMBL485351 | — | — | 1 | 7.60 |
| CHEMBL484950 | — | — | 1 | 7.57 |
| CHEMBL560630 | — | — | 1 | 7.31 |
| CHEMBL564449 | — | — | 1 | 7.29 |
| CHEMBL557682 | — | — | 1 | 7.28 |
| CHEMBL564941 | — | — | 1 | 7.24 |
| CHEMBL561617 | — | — | 1 | 7.23 |
| CHEMBL557279 | — | — | 1 | 7.08 |
| CHEMBL549668 | — | — | 1 | 6.98 |
| CHEMBL565183 | — | — | 1 | 6.94 |
| CHEMBL564290 | — | — | 1 | 6.92 |
| CHEMBL554941 | — | — | 1 | 6.84 |
| CHEMBL560556 | — | — | 1 | 6.82 |
| CHEMBL562416 | — | — | 1 | 6.73 |
| CHEMBL549469 | — | — | 1 | 6.68 |
| CHEMBL562497 | — | — | 1 | 6.66 |
| CHEMBL552033 | — | — | 1 | 6.64 |
| CHEMBL556460 | — | — | 1 | 6.60 |
| CHEMBL562415 | — | — | 1 | 6.35 |
| CHEMBL552500 | — | — | 1 | 6.24 |
| CHEMBL549322 | — | — | 1 | 6.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL484951 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL485186 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL484006 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL482778 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL561421 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL572878 | TOZASERTIB | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL482779 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL484609 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL563682 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL485351 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL484950 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL560630 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL564449 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL557682 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL564941 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL561617 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL557279 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL549668 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL565183 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL564290 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL554941 | — | Ki | = | 145.0 | nM | 6.84 |
| CHEMBL560556 | — | Ki | = | 153.0 | nM | 6.82 |
| CHEMBL562416 | — | Ki | = | 185.0 | nM | 6.73 |
| CHEMBL549469 | — | Ki | = | 207.0 | nM | 6.68 |
| CHEMBL562497 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL552033 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL556460 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL562415 | — | Ki | = | 445.0 | nM | 6.35 |
| CHEMBL552500 | — | Ki | = | 575.0 | nM | 6.24 |
| CHEMBL549322 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL564459 | — | Ki | = | 675.0 | nM | 6.17 |
| CHEMBL551634 | — | Ki | = | 995.0 | nM | 6.00 |
| CHEMBL551633 | — | Ki | > | 1100.0 | nM | - |
| CHEMBL562157 | — | Ki | > | 1100.0 | nM | - |
| CHEMBL561834 | — | Ki | > | 1100.0 | nM | - |
| CHEMBL560158 | — | Ki | > | 1100.0 | nM | - |
| CHEMBL559900 | — | Ki | > | 40.0 | nM | - |
| CHEMBL552385 | — | Ki | > | 40.0 | nM | - |