Assay Detail
Binding
CHEMBL993739
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Inhibition of aurora B kinase
40
Total Activities
40
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery and development of aurora kinase inhibitors as anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 7.46 | 9.00 |
| Ki | 3 | 7.66 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL215275 | — | — | 1 | 9.00 |
| CHEMBL381724 | — | — | 1 | 9.00 |
| CHEMBL216769 | — | — | 1 | 8.70 |
| CHEMBL217804 | — | — | 1 | 8.70 |
| CHEMBL495727 | AT-9283 | 2.0 | 1 | 8.52 |
| CHEMBL201307 | — | — | 1 | 8.15 |
| CHEMBL215322 | — | — | 1 | 8.12 |
| CHEMBL484951 | — | — | 1 | 8.10 |
| CHEMBL485186 | — | — | 1 | 8.02 |
| CHEMBL484006 | — | — | 1 | 7.96 |
| CHEMBL472193 | — | — | 1 | 7.85 |
| CHEMBL482778 | — | — | 1 | 7.85 |
| CHEMBL482779 | — | — | 1 | 7.75 |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 7.75 |
| CHEMBL482967 | CYC-116 | 1.0 | 1 | 7.72 |
| CHEMBL484609 | — | — | 1 | 7.70 |
| CHEMBL485351 | — | — | 1 | 7.60 |
| CHEMBL484950 | — | — | 1 | 7.57 |
| CHEMBL482774 | — | — | 1 | 7.38 |
| CHEMBL385872 | — | — | 1 | 7.32 |
| CHEMBL485337 | — | — | 1 | 7.24 |
| CHEMBL402548 | DANUSERTIB | 2.0 | 1 | 7.10 |
| CHEMBL427787 | — | — | 1 | 7.00 |
| CHEMBL472202 | — | — | 1 | 6.92 |
| CHEMBL202721 | — | — | 1 | 6.89 |
| CHEMBL259084 | MLN-8054 | 1.0 | 1 | 6.76 |
| CHEMBL514409 | HESPERADIN | — | 1 | 6.60 |
| CHEMBL482968 | ENMD-2076 | 2.0 | 1 | 6.54 |
| CHEMBL385266 | — | — | 1 | 6.52 |
| CHEMBL484601 | — | — | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL215275 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL381724 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL217804 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL216769 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL495727 | AT-9283 | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL201307 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL215322 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL484951 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL485186 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL484006 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL482778 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL472193 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL482779 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL572878 | TOZASERTIB | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL482967 | CYC-116 | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL484609 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL485351 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL484950 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL482774 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL385872 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL485337 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL402548 | DANUSERTIB | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL427787 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL472202 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL202721 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL259084 | MLN-8054 | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL514409 | HESPERADIN | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL482968 | ENMD-2076 | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL385266 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL484601 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL384575 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL483158 | ALISERTIB | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL217748 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL518981 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL190252 | — | IC50 | - | — | - | |
| CHEMBL359482 | — | Ki | - | — | - | |
| CHEMBL214848 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL214849 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL216053 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL215152 | DEFOSBARASERTIB | IC50 | < | 1.0 | nM | - |