Assay Detail
Binding
CHEMBL1031478
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Displacement of [125I]echistatin from integrin alphaVbeta5 receptor in human placenta by microplate scintillation counter
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Morpholine-based RGD-cyclopentapeptides as alphavbeta3/alphavbeta5 integrin ligands: role of configuration towards receptor binding affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.61 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL429876 | CILENGITIDE | 3.0 | 1 | 9.89 |
| CHEMBL460012 | — | — | 1 | 9.05 |
| CHEMBL452724 | — | — | 1 | 7.82 |
| CHEMBL443362 | — | — | 1 | 7.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL429876 | CILENGITIDE | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL460012 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL452724 | — | IC50 | = | 15.1 | nM | 7.82 |
| CHEMBL443362 | — | IC50 | = | 21.0 | nM | 7.68 |