Assay Detail
ADMET
CHEMBL1031512
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Cell membrane permeabilization in human WS1 cells assessed as drug level causing decrease in calcein fluorescence
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | WS1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 4.81 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502407 | — | — | 1 | 5.55 |
| CHEMBL444941 | HEDERACOLCHISIDE A1 | — | 1 | 5.52 |
| CHEMBL447565 | ALPHA-HEDERIN | — | 1 | 4.62 |
| CHEMBL452911 | — | — | 1 | 4.29 |
| CHEMBL479310 | HEDERACOLCHISIDE A | — | 1 | 4.07 |
| CHEMBL503608 | — | — | 1 | - |
| CHEMBL237890 | — | — | 1 | - |
| CHEMBL23236 | BETULIN | — | 1 | - |
| CHEMBL486400 | HEDERAGENIN | — | 1 | - |
| CHEMBL168 | OLEANOLIC_ACID | — | 1 | - |
| CHEMBL502465 | — | — | 1 | - |
| CHEMBL502316 | — | — | 1 | - |
| CHEMBL237708 | — | — | 1 | - |
| CHEMBL396877 | — | — | 1 | - |
| CHEMBL500370 | — | — | 1 | - |
| CHEMBL269277 | BETULINIC ACID | 1.0 | 1 | - |
| CHEMBL396425 | — | — | 1 | - |
| CHEMBL499529 | — | — | 1 | - |
| CHEMBL500006 | — | — | 1 | - |
| CHEMBL503523 | — | — | 1 | - |
| CHEMBL500097 | — | — | 1 | - |
| CHEMBL503115 | — | — | 1 | - |
| CHEMBL499456 | — | — | 1 | - |
| CHEMBL396944 | — | — | 1 | - |
| CHEMBL397553 | — | — | 1 | - |
| CHEMBL455747 | Hederagenin-3-O-beta-D-glucopyranoside | — | 1 | - |
| CHEMBL509430 | — | — | 1 | - |
| CHEMBL509927 | — | — | 1 | - |
| CHEMBL509798 | — | — | 1 | - |
| CHEMBL444506 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502407 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL444941 | HEDERACOLCHISIDE A1 | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL447565 | ALPHA-HEDERIN | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL452911 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL479310 | HEDERACOLCHISIDE A | IC50 | = | 86000.0 | nM | 4.07 |
| CHEMBL486400 | HEDERAGENIN | IC50 | > | 200000.0 | nM | - |
| CHEMBL507049 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL168 | OLEANOLIC_ACID | IC50 | > | 200000.0 | nM | - |
| CHEMBL502465 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL502316 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL237708 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL396877 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL500370 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL269277 | BETULINIC ACID | IC50 | > | 200000.0 | nM | - |
| CHEMBL396425 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL237890 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL237068 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL396650 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL501076 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL453268 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL23236 | BETULIN | IC50 | > | 200000.0 | nM | - |
| CHEMBL503608 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL499529 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL500006 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL503523 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL500097 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL503115 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL499456 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL396944 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL397553 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL455747 | Hederagenin-3-O-beta-D-glucopyranoside | IC50 | = | 102000.0 | nM | - |
| CHEMBL509430 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL509927 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL509798 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL444506 | — | IC50 | > | 200000.0 | nM | - |