Assay Detail
Binding
CHEMBL1031545
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Displacement of [125I]RTI55 from human DAT expressed in HEK cells
36
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 36 | 5.09 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.43 |
| CHEMBL504028 | — | — | 1 | 6.29 |
| CHEMBL458639 | — | — | 1 | 6.04 |
| CHEMBL456639 | — | — | 1 | 5.82 |
| CHEMBL460204 | — | — | 1 | 5.47 |
| CHEMBL455221 | — | — | 1 | 5.41 |
| CHEMBL459367 | — | — | 1 | 5.34 |
| CHEMBL457966 | — | — | 1 | 5.26 |
| CHEMBL461268 | — | — | 1 | 5.21 |
| CHEMBL457968 | — | — | 1 | 5.20 |
| CHEMBL462311 | — | — | 1 | 5.19 |
| CHEMBL447825 | — | — | 1 | 5.17 |
| CHEMBL450907 | — | — | 2 | 5.14 |
| CHEMBL460407 | — | — | 1 | 5.13 |
| CHEMBL456638 | — | — | 1 | 5.07 |
| CHEMBL511500 | — | — | 1 | 4.84 |
| CHEMBL460406 | — | — | 1 | 4.79 |
| CHEMBL456221 | — | — | 1 | 4.57 |
| CHEMBL456223 | — | — | 1 | 4.52 |
| CHEMBL512736 | — | — | 1 | 4.48 |
| CHEMBL450769 | — | — | 1 | 4.46 |
| CHEMBL457967 | — | — | 1 | 4.37 |
| CHEMBL456222 | — | — | 1 | 4.29 |
| CHEMBL450987 | — | — | 1 | 4.01 |
| CHEMBL456017 | — | — | 1 | - |
| CHEMBL442843 | — | — | 1 | - |
| CHEMBL451837 | — | — | 1 | - |
| CHEMBL448912 | — | — | 1 | - |
| CHEMBL508678 | — | — | 1 | - |
| CHEMBL452928 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370805 | COCAINE | Ki | = | 371.0 | nM | 6.43 |
| CHEMBL504028 | — | Ki | = | 512.0 | nM | 6.29 |
| CHEMBL458639 | — | Ki | = | 916.0 | nM | 6.04 |
| CHEMBL456639 | — | Ki | = | 1505.0 | nM | 5.82 |
| CHEMBL460204 | — | Ki | = | 3387.0 | nM | 5.47 |
| CHEMBL455221 | — | Ki | = | 3868.0 | nM | 5.41 |
| CHEMBL459367 | — | Ki | = | 4576.0 | nM | 5.34 |
| CHEMBL457966 | — | Ki | = | 5498.0 | nM | 5.26 |
| CHEMBL461268 | — | Ki | = | 6117.0 | nM | 5.21 |
| CHEMBL457968 | — | Ki | = | 6376.0 | nM | 5.20 |
| CHEMBL462311 | — | Ki | = | 6500.0 | nM | 5.19 |
| CHEMBL447825 | — | Ki | = | 6830.0 | nM | 5.17 |
| CHEMBL450907 | — | Ki | = | 7307.0 | nM | 5.14 |
| CHEMBL460407 | — | Ki | = | 7328.0 | nM | 5.13 |
| CHEMBL456638 | — | Ki | = | 8519.0 | nM | 5.07 |
| CHEMBL511500 | — | Ki | = | 14500.0 | nM | 4.84 |
| CHEMBL460406 | — | Ki | = | 16370.0 | nM | 4.79 |
| CHEMBL450907 | — | Ki | = | 21190.0 | nM | 4.67 |
| CHEMBL456221 | — | Ki | = | 27240.0 | nM | 4.57 |
| CHEMBL456223 | — | Ki | = | 30320.0 | nM | 4.52 |
| CHEMBL512736 | — | Ki | = | 32940.0 | nM | 4.48 |
| CHEMBL450769 | — | Ki | = | 34790.0 | nM | 4.46 |
| CHEMBL457967 | — | Ki | = | 42760.0 | nM | 4.37 |
| CHEMBL456222 | — | Ki | = | 51020.0 | nM | 4.29 |
| CHEMBL450987 | — | Ki | = | 97180.0 | nM | 4.01 |
| CHEMBL459391 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL459390 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL451652 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL447750 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL511163 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL452928 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL508678 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL448912 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL451837 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL442843 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL456017 | — | Ki | > | 10000.0 | nM | - |