Assay Detail
Binding
CHEMBL1031850
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of F-BakBH3 from Bcl-xL by fluorescence polarization assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.90 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL539481 | — | — | 1 | 6.57 |
| CHEMBL538616 | — | — | 1 | 6.12 |
| CHEMBL552287 | — | — | 1 | 6.10 |
| CHEMBL554545 | — | — | 1 | 6.10 |
| CHEMBL541427 | — | — | 1 | 6.07 |
| CHEMBL541496 | — | — | 1 | 6.03 |
| CHEMBL541004 | — | — | 1 | 5.96 |
| CHEMBL552735 | — | — | 1 | 5.46 |
| CHEMBL551288 | APOGOSSYPOL | — | 1 | 5.43 |
| CHEMBL553474 | — | — | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL539481 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL538616 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL552287 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL554545 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL541427 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL541496 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL541004 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL552735 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL551288 | APOGOSSYPOL | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL553474 | — | IC50 | = | 6300.0 | nM | 5.20 |