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Assay Detail

CHEMBL1031903

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Phototoxicity in transformed CHO cells after 24 hrs incubation in dark by WST1 assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Cricetulus griseus
Cell Type CHO
Confidence 1 — Organism
Curated By Autocuration

Target

CHO (CHEMBL613853)
Type CELL-LINE
Organism Cricetulus griseus

Publication

Photo-inducible cytotoxic and clastogenic activities of 3,6-di-substituted acridines obtained by acylation of proflavine.
Benchabane Y, Di Giorgio C, Boyer G, Sabatier AS, Allegro D, Peyrot V, De Méo M.
Eur J Med Chem (2009) 44 : 2459 -2467
PubMed 19217190 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 5.00 6.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL560753 1 6.96
CHEMBL55400 PROFLAVINE 2.0 1 5.96
CHEMBL552228 1 5.60
CHEMBL561016 1 5.21
CHEMBL570075 1 4.80
CHEMBL244308 1 4.62
CHEMBL244120 1 4.41
CHEMBL551286 1 4.40
CHEMBL564562 1 4.37
CHEMBL552029 1 4.37
CHEMBL244686 1 4.34
CHEMBL562920 1 -
CHEMBL557268 1 -
CHEMBL551487 1 -
CHEMBL244685 1 -
CHEMBL244684 1 -
CHEMBL539409 1 -
CHEMBL428219 1 -
CHEMBL244683 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL560753 IC50 = 110.0 nM 6.96
CHEMBL55400 PROFLAVINE IC50 = 1100.0 nM 5.96
CHEMBL552228 IC50 = 2500.0 nM 5.60
CHEMBL561016 IC50 = 6100.0 nM 5.21
CHEMBL570075 IC50 = 15800.0 nM 4.80
CHEMBL244308 IC50 = 23800.0 nM 4.62
CHEMBL244120 IC50 = 38900.0 nM 4.41
CHEMBL551286 IC50 = 40200.0 nM 4.40
CHEMBL564562 IC50 = 43100.0 nM 4.37
CHEMBL552029 IC50 = 42300.0 nM 4.37
CHEMBL244686 IC50 = 45200.0 nM 4.34
CHEMBL562920 IC50 > 50000.0 nM -
CHEMBL557268 IC50 > 50000.0 nM -
CHEMBL551487 IC50 > 50000.0 nM -
CHEMBL244685 IC50 > 50000.0 nM -
CHEMBL244684 IC50 > 50000.0 nM -
CHEMBL539409 IC50 > 50000.0 nM -
CHEMBL428219 IC50 > 50000.0 nM -
CHEMBL244683 IC50 > 50000.0 nM -