Evidence Snapshot

CHO

CHEMBL613853 CELL-LINE Cricetulus griseus

Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T20:59:12Z

Source · ChEMBL 36 via Core Engine Freshness · Sep 14, 2026, 5:59 AM KST As of · Sep 13, 2026

ChEMBL ChEMBL 36 CHEMBL613853

Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats CHO as ChEMBL target CHEMBL613853. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor

CHO

CELL-LINE · Cricetulus griseus

As of 2026-09-13

ChEMBL target ID

CHEMBL613853

Primary anchor for compounds, assays, approvals, and exports

ChEMBL 36 via Core Engine As of 2026-09-13

www.ebi.ac.uk

Disease evidence contract

Open Targets-ready proxy

ChEMBL drug mechanism + indication proxy

ChEMBL drug mechanism + indication proxy As of 2026-09-13

www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why CHO matters

As of 2026-09-13

CHO is reviewed as CHO; the current evidence base includes 15 approved drugs, 3438 compounds, and 751 assays, with lead potency reaching pChEMBL 10.3.

Protein context

CHO

Review this target as CHO.

Protein source · UniProt accession via ChEMBL component mapping

Disease context

Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record

Activity base

Portfolio and assay base

ChEMBL currently tracks 15 approved drugs, 3438 compounds, and 751 assays for this target. The dominant activity type is IC50. CHEMBL26291 is the current potency anchor at pChEMBL 10.3.

Use CHEMBL26291 as the tractability anchor when discussing potency (pChEMBL 10.3).

Activity source · ChEMBL 36 via Core Engine

15 approved pChEMBL 10.3

Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?

Review-ready Target Rationale

One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why CHO matters before drilling into raw source blocks.

Jump to Review Rationale

Need stable protein naming or accession mapping?

UniProt Target Context

UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract, not just the summarized rationale.

Open Protein Context

Need disease fit or evidence level for program framing?

Disease Relevance & Evidence Level

ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

3438

Total Compounds

751

Total Assays

Approved Drugs

IC50: 2381.0, EC50: 58.0, KD: 21.0

Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Compound	pChEMBL	Type	Phase
No preferred name CHEMBL26291	10.3	IC50	Clinical
No preferred name CHEMBL405105	10.0	IC50	—
No preferred name CHEMBL2371603	9.9	EC50	—
No preferred name CHEMBL2371608	9.8	EC50	—
No preferred name CHEMBL50588	9.7	IC50	Approved