Compound Detail
CHEMBL26291
NITRACRINE 🧪 Phase II
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL26291 |
| Name | NITRACRINE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | YMVWGSQGCWCDGW-UHFFFAOYSA-N |
4
Targets
7
Activities
1
Assay Types
2
PK Parameters
20
Publications
2
Known Names
Molecular Properties
324.4
MW (Da)
3.66
ALogP
5
HBA
1
HBD
71.3
PSA (Ų)
0.32
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Activity Summary
IC50 7 meas. best 10.31
Target Activity Profile
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 7.3 | hr | Cricetulus griseus |
| T1/2 | 0.84 | hr | Cricetulus griseus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| CHO | IC50 | = | 0.049 | nM | 10.31 | Inhibitory activity of compound for AA8 cells to reduce cell density by 50% (exp... | 2909741 |
| UV4 | IC50 | = | 0.66 | nM | 9.18 | Inhibitory concentration required to reduce cell density in UV-4 cells to 50% of... | 2909741 |
| UV4 | IC50 | = | 2.0 | nM | 8.7 | Inhibitory ativity to reduce cell density by 50% of repair deffective mutant UV-... | 2909741 |
| CHO-AA8 | IC50 | = | 24.0 | nM | 7.62 | Growth inhibitory activity against CHO subline AA8 cells exposed for 18 hr under... | 1479583 |
| CHO-AA8 | IC50 | = | 24.0 | nM | 7.62 | Inhibitory activity against aerobic growth of AA8 cells. | 8691448 |
| CHO-AA8 | IC50 | = | 26.3 | nM | 7.58 | Inhibitory activity to reduce cell density by 50% of AA8 cells under aerobic con... | 2909741 |
| ADMET | IC50 | = | 26.3 | nM | 7.58 | Tested for the concentration of the drug to reduce cell numbers to 50 percent of... | 2329552 |
Literature References
Data from ChEMBL 36 via Core Engine