Assay Detail
Functional
CHEMBL618643
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Inhibitory activity against aerobic growth of AA8 cells.
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | CHO-AA8 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Hypoxia-selective antitumor agents. 13. Effects of acridine substitution on the hypoxia-selective cytotoxicity and metabolic reduction of the bis-bioreductive agent nitracrine N-oxide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.84 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26291 | NITRACRINE | 2.0 | 1 | 7.62 |
| CHEMBL312975 | — | — | 1 | 7.28 |
| CHEMBL82457 | — | — | 1 | 6.72 |
| CHEMBL312249 | — | — | 1 | 6.33 |
| CHEMBL83184 | — | — | 1 | 6.29 |
| CHEMBL432568 | — | — | 1 | 5.57 |
| CHEMBL313535 | — | — | 1 | 5.54 |
| CHEMBL85372 | — | — | 1 | 5.27 |
| CHEMBL310560 | — | — | 1 | 5.17 |
| CHEMBL419859 | — | — | 1 | 4.33 |
| CHEMBL85107 | — | — | 1 | 4.08 |
| CHEMBL84223 | — | — | 1 | - |
| CHEMBL309873 | — | — | 1 | - |
| CHEMBL312061 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26291 | NITRACRINE | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL312975 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL82457 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL312249 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL83184 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL432568 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL313535 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL85372 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL310560 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL419859 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL85107 | — | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL84223 | — | IC50 | = | 1960000.0 | nM | - |
| CHEMBL309873 | — | IC50 | = | 150000.0 | nM | - |
| CHEMBL312061 | — | IC50 | = | 130000.0 | nM | - |