Assay Detail
Functional
CHEMBL813693
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Inhibitory concentration required to reduce cell density in UV-4 cells to 50% of controls (cells were exposed to compound for 4 days continuously)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | UV4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Hypoxia-selective antitumor agents. 2. Electronic effects of 4-substituents on the mechanisms of cytotoxicity and metabolic stability of nitracrine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.72 | 9.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL103637 | — | — | 1 | 9.21 |
| CHEMBL26291 | NITRACRINE | 2.0 | 1 | 9.18 |
| CHEMBL312975 | — | — | 1 | 8.78 |
| CHEMBL103310 | — | — | 1 | 8.70 |
| CHEMBL312249 | — | — | 1 | 7.84 |
| CHEMBL317248 | — | — | 1 | 6.39 |
| CHEMBL103914 | — | — | 1 | 6.23 |
| CHEMBL101478 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL103637 | — | IC50 | = | 0.62 | nM | 9.21 |
| CHEMBL26291 | NITRACRINE | IC50 | = | 0.66 | nM | 9.18 |
| CHEMBL312975 | — | IC50 | = | 1.65 | nM | 8.78 |
| CHEMBL103310 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL312249 | — | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL317248 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL103914 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL101478 | — | IC50 | = | 3450.0 | nM | 5.46 |