Assay Detail
Functional
CHEMBL813692
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Inhibitory ativity to reduce cell density by 50% of repair deffective mutant UV-4 cells in 96-well cultures under aerobic conditions
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | UV4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Hypoxia-selective antitumor agents. 2. Electronic effects of 4-substituents on the mechanisms of cytotoxicity and metabolic stability of nitracrine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.77 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26291 | NITRACRINE | 2.0 | 1 | 8.70 |
| CHEMBL103637 | — | — | 1 | 8.48 |
| CHEMBL312975 | — | — | 1 | 8.10 |
| CHEMBL103310 | — | — | 1 | 7.92 |
| CHEMBL312249 | — | — | 1 | 7.20 |
| CHEMBL103914 | — | — | 1 | 5.71 |
| CHEMBL317248 | — | — | 1 | 5.21 |
| CHEMBL101478 | — | — | 1 | 4.94 |
| CHEMBL421212 | — | — | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26291 | NITRACRINE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL103637 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL312975 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL103310 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL312249 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL103914 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL317248 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL101478 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL421212 | — | IC50 | = | 19400.0 | nM | 4.71 |