Assay Detail
Functional
CHEMBL1032136
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Antimalarial activity after 48 hrs against atovaquone-resistant Plasmodium falciparum FCR3 by [3H]hypoxanthine uptake
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and structure-activity relationships of (1H-pyridin-4-ylidene)amines as potential antimalarials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.59 | 7.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.29 |
| CHEMBL559643 | — | — | 1 | 5.77 |
| CHEMBL565121 | — | — | 1 | 5.74 |
| CHEMBL549945 | — | — | 1 | 5.73 |
| CHEMBL1450 | ATOVAQUONE | 4.0 | 1 | 5.72 |
| CHEMBL555880 | — | — | 1 | 5.68 |
| CHEMBL564704 | — | — | 1 | 5.66 |
| CHEMBL562098 | — | — | 1 | 5.66 |
| CHEMBL560430 | — | — | 1 | 5.65 |
| CHEMBL557075 | — | — | 1 | 5.55 |
| CHEMBL556259 | — | — | 1 | 5.54 |
| CHEMBL564346 | — | — | 1 | 5.50 |
| CHEMBL446918 | CLOPIDOL | 2.0 | 1 | 5.47 |
| CHEMBL561221 | — | — | 1 | 5.45 |
| CHEMBL551552 | — | — | 1 | 5.43 |
| CHEMBL564236 | — | — | 1 | 5.40 |
| CHEMBL556672 | — | — | 1 | 5.29 |
| CHEMBL559073 | — | — | 1 | 5.10 |
| CHEMBL556257 | — | — | 1 | 5.09 |
| CHEMBL565089 | — | — | 1 | 5.01 |
| CHEMBL551494 | — | — | 1 | - |
| CHEMBL560557 | — | — | 1 | - |
| CHEMBL556258 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL559643 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL565121 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL549945 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL1450 | ATOVAQUONE | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL555880 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL564704 | — | IC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL562098 | — | IC50 | = | 2170.0 | nM | 5.66 |
| CHEMBL560430 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL557075 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL556259 | — | IC50 | = | 2890.0 | nM | 5.54 |
| CHEMBL564346 | — | IC50 | = | 3190.0 | nM | 5.50 |
| CHEMBL446918 | CLOPIDOL | IC50 | = | 3370.0 | nM | 5.47 |
| CHEMBL561221 | — | IC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL551552 | — | IC50 | = | 3740.0 | nM | 5.43 |
| CHEMBL564236 | — | IC50 | = | 3950.0 | nM | 5.40 |
| CHEMBL556672 | — | IC50 | = | 5120.0 | nM | 5.29 |
| CHEMBL559073 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL556257 | — | IC50 | = | 8090.0 | nM | 5.09 |
| CHEMBL565089 | — | IC50 | = | 9860.0 | nM | 5.01 |
| CHEMBL551494 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL560557 | — | IC50 | > | 8900000.0 | nM | - |
| CHEMBL556258 | — | IC50 | > | 10000.0 | nM | - |