Compound Detail
CHEMBL446918
CLOPIDOL 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL446918 |
| Name | CLOPIDOL |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | ZDPIZLCVJAAHHR-UHFFFAOYSA-N |
3
Targets
11
Activities
2
Assay Types
0
PK Parameters
20
Publications
2
Known Names
Molecular Properties
192.0
MW (Da)
2.71
ALogP
2
HBA
1
HBD
33.1
PSA (Ų)
0.68
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Activity Summary
IC50 10 meas. best 5.84
EC50 1 meas. best 4.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium berghei CHEMBL612653 | IC50 | 5.84 | 5.84 | 1460.0 | 1 |
| Plasmodium falciparum CHEMBL364 | IC50 | 5.47 | 5.06 | 3370.0 | 3 |
| NON-PROTEIN TARGET CHEMBL3879801 | EC50 | 4.7 | 4.7 | 20000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasmodium berghei | IC50 | = | 1460.0 | nM | 5.84 | Antiplasmodial activity against liver stage Plasmodium berghei infected in human... | 23701465 |
| Plasmodium falciparum | IC50 | = | 3370.0 | nM | 5.47 | Antimalarial activity after 48 hrs against atovaquone-resistant Plasmodium falci... | 19467600 |
| Plasmodium falciparum | IC50 | = | 9730.0 | nM | 5.01 | Antimalarial activity after 48 hrs against chloroquine-resistant Plasmodium falc... | 19467600 |
| NON-PROTEIN TARGET | EC50 | = | 20000.0 | nM | 4.7 | Antimicrobial activity against Plasmodium | 23927720 |
| Plasmodium falciparum | IC50 | = | 20000.0 | nM | 4.7 | Antimalarial activity against Plasmodium falciparum T9-96 infected Rhesus positi... | 18396855 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 137981 | 10.1021/jm00212a010 | Enterococcus faecium | 5 |
| 137981 | 10.1021/jm00212a010 | NON-PROTEIN TARGET | 4 |
| 137981 | 10.1021/jm00212a010 | Lacticaseibacillus casei | 4 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 137981 | 10.1021/jm00212a010 | Plasmodium berghei | 2 |
| 23701465 | 10.1021/jm400246e | Unchecked | 2 |
| 19467600 | 10.1016/j.bmcl.2009.05.017 | Plasmodium falciparum | 2 |
| 23571415 | 10.1124/mol.112.084152 | Solute carrier organic anion transporter family member 1B3 | 1 |
| 23571415 | 10.1124/mol.112.084152 | Solute carrier organic anion transporter family member 1B1 | 1 |
| 23927720 | 10.1021/jm400314m | NON-PROTEIN TARGET | 1 |
| 23701465 | 10.1021/jm400246e | Plasmodium berghei | 1 |
| 137981 | 10.1021/jm00212a010 | Unchecked | 1 |
| 137981 | 10.1021/jm00212a010 | Escherichia coli | 1 |
| 23701465 | 10.1021/jm400246e | HepG2 | 1 |
| - | 10.1101/2020.04.03.023846 | SARS-CoV-2 | 1 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| - | 10.1101/2020.04.21.054387 | SARS-CoV-2 | 1 |
| 18396855 | 10.1021/jm0705760 | Plasmodium yoelii | 1 |
Data from ChEMBL 36 via Core Engine