Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL989656

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antimalarial activity against Plasmodium falciparum T9-96 infected Rhesus positive human erythrocytes by [3H]hypoxanthine uptake
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Synthesis and structure-activity relationships of 4-pyridones as potential antimalarials.
Yeates CL, Batchelor JF, Capon EC, Cheesman NJ, Fry M, Hudson AT, Pudney M, Trimming H, Woolven J, Bueno JM, Chicharro J, Fernández E, Fiandor JM, Gargallo-Viola D, Gómez de las Heras F, Herreros E, León ML.
J Med Chem (2008) 51 : 2845 -2852
PubMed 18396855 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 6.82 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1450 ATOVAQUONE 4.0 1 8.52
CHEMBL512802 1 7.52
CHEMBL468198 1 7.52
CHEMBL505435 1 7.52
CHEMBL498894 1 7.52
CHEMBL469011 1 7.52
CHEMBL467599 1 7.52
CHEMBL467584 1 7.52
CHEMBL466533 1 7.40
CHEMBL468758 1 7.40
CHEMBL502850 1 7.30
CHEMBL467739 1 7.22
CHEMBL468388 1 7.22
CHEMBL76 CHLOROQUINE 4.0 1 7.16
CHEMBL468757 1 6.82
CHEMBL467583 1 6.80
CHEMBL443178 1 6.60
CHEMBL513328 1 6.40
CHEMBL468024 1 6.35
CHEMBL468199 1 6.30
CHEMBL468025 1 5.66
CHEMBL467738 1 5.60
CHEMBL504695 1 5.40
CHEMBL505208 1 4.96
CHEMBL446918 CLOPIDOL 2.0 1 4.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1450 ATOVAQUONE IC50 = 3.0 nM 8.52
CHEMBL512802 IC50 = 30.0 nM 7.52
CHEMBL468198 IC50 = 30.0 nM 7.52
CHEMBL505435 IC50 = 30.0 nM 7.52
CHEMBL498894 IC50 = 30.0 nM 7.52
CHEMBL469011 IC50 = 30.0 nM 7.52
CHEMBL467599 IC50 = 30.0 nM 7.52
CHEMBL467584 IC50 = 30.0 nM 7.52
CHEMBL466533 IC50 = 40.0 nM 7.40
CHEMBL468758 IC50 = 40.0 nM 7.40
CHEMBL502850 IC50 = 50.0 nM 7.30
CHEMBL467739 IC50 = 60.0 nM 7.22
CHEMBL468388 IC50 = 60.0 nM 7.22
CHEMBL76 CHLOROQUINE IC50 = 70.0 nM 7.16
CHEMBL468757 IC50 = 150.0 nM 6.82
CHEMBL467583 IC50 = 160.0 nM 6.80
CHEMBL443178 IC50 = 250.0 nM 6.60
CHEMBL513328 IC50 = 400.0 nM 6.40
CHEMBL468024 IC50 = 450.0 nM 6.35
CHEMBL468199 IC50 = 500.0 nM 6.30
CHEMBL468025 IC50 = 2200.0 nM 5.66
CHEMBL467738 IC50 = 2500.0 nM 5.60
CHEMBL504695 IC50 = 4000.0 nM 5.40
CHEMBL505208 IC50 = 11000.0 nM 4.96
CHEMBL446918 CLOPIDOL IC50 = 20000.0 nM 4.70