Assay Detail
Functional
CHEMBL1032508
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Antiviral activity against HIV1 3B in human H9 cells assessed as inhibition of virus-induced cytopathic effect by formazan-based conventional colorimetric technique
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | H9 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Natural product-based anti-HIV drug discovery and development facilitated by the NCI developmental therapeutics program.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.77 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 9.00 |
| CHEMBL853 | ZALCITABINE | 4.0 | 1 | 9.00 |
| CHEMBL1460 | DIDANOSINE | 4.0 | 1 | 8.25 |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 7.22 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | 7.22 |
| CHEMBL501916 | LODENOSINE | 2.0 | 1 | 5.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL853 | ZALCITABINE | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1460 | DIDANOSINE | EC50 | = | 5.6 | nM | 8.25 |
| CHEMBL991 | STAVUDINE | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL141 | LAMIVUDINE | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL501916 | LODENOSINE | EC50 | = | 1160.0 | nM | 5.94 |