Assay Detail
Binding
CHEMBL1032963
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of peptidase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.17 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL563693 | — | — | 1 | 7.16 |
| CHEMBL561639 | — | — | 1 | 7.09 |
| CHEMBL570775 | — | — | 1 | 6.68 |
| CHEMBL538940 | — | — | 1 | 4.41 |
| CHEMBL539640 | — | — | 1 | 3.98 |
| CHEMBL111234 | DIHYDRORESVERATROL | — | 1 | 3.84 |
| CHEMBL558285 | — | — | 1 | 3.69 |
| CHEMBL194009 | — | — | 1 | 3.51 |
| CHEMBL563692 | — | — | 1 | 3.49 |
| CHEMBL165 | RESVERATROL | 3.0 | 1 | 3.44 |
| CHEMBL549343 | — | — | 1 | 2.97 |
| CHEMBL264669 | — | — | 1 | 2.88 |
| CHEMBL562164 | — | — | 1 | 2.83 |
| CHEMBL563196 | — | — | 1 | 2.44 |
| CHEMBL483790 | — | — | 1 | - |
| CHEMBL404923 | — | — | 1 | - |
| CHEMBL555013 | — | — | 1 | - |
| CHEMBL555457 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL563693 | — | IC50 | = | 68.5 | nM | 7.16 |
| CHEMBL561639 | — | IC50 | = | 80.5 | nM | 7.09 |
| CHEMBL570775 | — | IC50 | = | 207.0 | nM | 6.68 |
| CHEMBL538940 | — | IC50 | = | 38900.0 | nM | 4.41 |
| CHEMBL539640 | — | IC50 | = | 106000.0 | nM | 3.98 |
| CHEMBL111234 | DIHYDRORESVERATROL | IC50 | = | 145000.0 | nM | 3.84 |
| CHEMBL558285 | — | IC50 | = | 202000.0 | nM | 3.69 |
| CHEMBL194009 | — | IC50 | = | 308000.0 | nM | 3.51 |
| CHEMBL563692 | — | IC50 | = | 321000.0 | nM | 3.49 |
| CHEMBL165 | RESVERATROL | IC50 | = | 366000.0 | nM | 3.44 |
| CHEMBL549343 | — | IC50 | = | 1077000.0 | nM | 2.97 |
| CHEMBL264669 | — | IC50 | = | 1321000.0 | nM | 2.88 |
| CHEMBL562164 | — | IC50 | = | 1491000.0 | nM | 2.83 |
| CHEMBL563196 | — | IC50 | = | 3673000.0 | nM | 2.44 |
| CHEMBL483790 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL404923 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL555013 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL555457 | — | IC50 | > | 1000000.0 | nM | - |