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Assay Detail

CHEMBL1033162

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to MAOA imidazoline binding site in rat brain mitochondrial homogenate assessed as 4-hydroxyquinoline production by spectrophotometry
18
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Tissue Brain
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amine oxidase [flavin-containing] A (CHEMBL3358)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Ultrasound promoted synthesis of 2-imidazolines in water: a greener approach toward monoamine oxidase inhibitors.
Sant' Anna Gda S, Machado P, Sauzem PD, Rosa FA, Rubin MA, Ferreira J, Bonacorso HG, Zanatta N, Martins MA.
Bioorg Med Chem Lett (2009) 19 : 546 -549
PubMed 19064321 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 16 4.80 5.31
IC50 2 4.55 4.90

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL13698 2 5.31
CHEMBL451230 1 4.89
CHEMBL503049 1 4.87
CHEMBL266155 BENAZOLINE 1 4.86
CHEMBL13633 1 4.80
CHEMBL404505 2 4.60
CHEMBL274548 1 4.54
CHEMBL489080 1 4.54
CHEMBL269197 1 -
CHEMBL501324 1 -
CHEMBL448710 1 -
CHEMBL457766 1 -
CHEMBL456894 1 -
CHEMBL457101 1 -
CHEMBL14410 1 -
CHEMBL13862 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL13698 Ki = 4860.0 nM 5.31
CHEMBL13698 IC50 = 12700.0 nM 4.90
CHEMBL451230 Ki = 12840.0 nM 4.89
CHEMBL503049 Ki = 13570.0 nM 4.87
CHEMBL266155 BENAZOLINE Ki = 13890.0 nM 4.86
CHEMBL13633 Ki = 15750.0 nM 4.80
CHEMBL404505 Ki = 24940.0 nM 4.60
CHEMBL489080 Ki = 28750.0 nM 4.54
CHEMBL274548 Ki = 28750.0 nM 4.54
CHEMBL404505 IC50 = 65000.0 nM 4.19
CHEMBL456894 Ki = 181400.0 nM -
CHEMBL13862 Ki > 1000000.0 nM -
CHEMBL14410 Ki > 1000000.0 nM -
CHEMBL457101 Ki > 1000000.0 nM -
CHEMBL457766 Ki > 1000000.0 nM -
CHEMBL448710 Ki = 166300.0 nM -
CHEMBL501324 Ki = 114400.0 nM -
CHEMBL269197 Ki = 102100.0 nM -