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Compound Detail

CHEMBL266155

BENAZOLINE
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c1ccc2cc(C3=NCCN3)ccc2c1

Basic Information

ChEMBL ID CHEMBL266155
Name BENAZOLINE
Phase Preclinical
Structure Type MOL
InChI Key BGWRJAXPPYHIRG-UHFFFAOYSA-N
5
Targets
6
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names

Molecular Properties

196.2
MW (Da)
2.19
ALogP
2
HBA
1
HBD
24.4
PSA (Ų)
0.74
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C13H12N2
MW 196.25
Aromatic Rings 2
Heavy Atoms 15
NP-Likeness -0.40

Activity Summary

Ki 6 meas. best 9.2

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Nischarin
CHEMBL3923
Ki 9.2 9.2 0.6 1
Unchecked
CHEMBL612545
Ki 9.07 9.07 0.9 1
Nischarin
CHEMBL5221
Ki 8.89 8.89 1.3 2
Amine oxidase [flavin-containing] B
CHEMBL2993
Ki 5.83 5.83 1490.0 1
Amine oxidase [flavin-containing] A
CHEMBL3358
Ki 4.86 4.86 13890.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
10737743 10.1021/jm991124t Nischarin 1
12723959 10.1021/jm021050c Unchecked 1
19064321 10.1016/j.bmcl.2008.03.001 Amine oxidase [flavin-containing] A 1
19064321 10.1016/j.bmcl.2008.03.001 Amine oxidase [flavin-containing] B 1
19064321 10.1016/j.bmcl.2008.03.001 Unchecked 1
- 10.1007/s00044-004-0023-9 Unchecked 1
- 10.1007/s00044-004-0023-9 Nischarin 1
27265687 10.1016/j.bmc.2016.05.043 Nischarin 1

Data from ChEMBL 36 via Core Engine