Assay Detail
Binding
CHEMBL3056380
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Binding affinity to I2 imidazoline binding site (unknown origin)
25
Total Activities
25
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Alpha2-Adrenergic Receptors in Intestinal Epithelial Cells: Mechanisms of Signaling, Role, and Regulation
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 6.50 | 9.07 |
| pKi | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL266155 | BENAZOLINE | — | 1 | 9.07 |
| CHEMBL14640 | — | — | 1 | 9.05 |
| CHEMBL275970 | TRACIZOLINE | — | 1 | 8.74 |
| CHEMBL14210 | PHENYZOLINE | — | 1 | 8.60 |
| CHEMBL13852 | CIRAZOLINE | 2.0 | 1 | 8.41 |
| CHEMBL93845 | — | — | 1 | 8.22 |
| CHEMBL13881 | PHENAMAZOLINE | 2.0 | 1 | 7.48 |
| CHEMBL761 | NAPHAZOLINE | 4.0 | 1 | 7.00 |
| CHEMBL2092860 | — | — | 1 | 7.00 |
| CHEMBL94022 | — | — | 1 | 6.91 |
| CHEMBL2092861 | — | — | 1 | 6.84 |
| CHEMBL13789 | — | — | 1 | 6.52 |
| CHEMBL501690 | — | — | 1 | 6.48 |
| CHEMBL337862 | — | — | 1 | 6.09 |
| CHEMBL134 | CLONIDINE | 4.0 | 1 | 6.02 |
| CHEMBL289480 | RILMENIDINE | 4.0 | 1 | 5.96 |
| CHEMBL1907831 | — | — | 1 | 5.60 |
| CHEMBL416893 | — | — | 1 | 5.54 |
| CHEMBL396013 | — | — | 1 | 5.14 |
| CHEMBL1907832 | — | — | 1 | 4.90 |
| CHEMBL242265 | — | — | 1 | 4.31 |
| CHEMBL2261603 | — | — | 1 | 4.00 |
| CHEMBL288951 | — | — | 1 | 4.00 |
| CHEMBL360803 | PI-CLONIDINE | — | 1 | 4.00 |
| CHEMBL1162356 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL266155 | BENAZOLINE | Ki | = | 0.8511 | nM | 9.07 |
| CHEMBL14640 | — | Ki | = | 0.8913 | nM | 9.05 |
| CHEMBL275970 | TRACIZOLINE | Ki | = | 1.82 | nM | 8.74 |
| CHEMBL14210 | PHENYZOLINE | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL13852 | CIRAZOLINE | Ki | = | 3.89 | nM | 8.41 |
| CHEMBL93845 | — | Ki | = | 6.026 | nM | 8.22 |
| CHEMBL13881 | PHENAMAZOLINE | Ki | = | 33.11 | nM | 7.48 |
| CHEMBL761 | NAPHAZOLINE | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL2092860 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL94022 | — | Ki | = | 123.03 | nM | 6.91 |
| CHEMBL2092861 | — | Ki | = | 144.54 | nM | 6.84 |
| CHEMBL13789 | — | Ki | = | 302.0 | nM | 6.52 |
| CHEMBL501690 | — | Ki | = | 331.13 | nM | 6.48 |
| CHEMBL337862 | — | Ki | = | 812.83 | nM | 6.09 |
| CHEMBL134 | CLONIDINE | Ki | = | 954.99 | nM | 6.02 |
| CHEMBL289480 | RILMENIDINE | Ki | = | 1096.48 | nM | 5.96 |
| CHEMBL1907831 | — | Ki | = | 2511.89 | nM | 5.60 |
| CHEMBL416893 | — | Ki | = | 2884.03 | nM | 5.54 |
| CHEMBL396013 | — | Ki | = | 7244.36 | nM | 5.14 |
| CHEMBL1907832 | — | Ki | = | 12589.25 | nM | 4.90 |
| CHEMBL242265 | — | Ki | = | 48977.88 | nM | 4.31 |
| CHEMBL2261603 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL288951 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL360803 | PI-CLONIDINE | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL1162356 | — | pKi | - | — | - |