Compound Detail
CHEMBL1162356
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL1162356 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OYLPBTPLAUXYTB-UHFFFAOYSA-N |
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
236.7
MW (Da)
1.12
ALogP
4
HBA
2
HBD
39.7
PSA (Ų)
0.77
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 5 meas. best 8.53
Target Activity Profile
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | Ki | = | 2.934 | nM | 8.53 | Displacement of [125I]PIC from human alpha2 adrenoceptors expressed in CHO cells | 18621536 |
| Nischarin | Ki | = | 6.918 | nM | 8.16 | Binding affinity to I1 imidazoline binding site in Rattus norvegicus (rat) PC12 ... | - |
| Nischarin | Ki | = | 28.18 | nM | 7.55 | Displacement of [125I]PIC from Imidazoline-1 receptor in rat PC12 cell membrane ... | 27265687 |
| Nischarin | Ki | = | 231.74 | nM | 6.63 | Displacement of [125I]PIC from human imidazoline receptor 1 in human platelets a... | 18621536 |
| Nischarin | Ki | = | 232.0 | nM | 6.63 | Displacement of [125I]PIC from human imidazoline receptor 1 in human platelets a... | 18621536 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18621536 | 10.1016/j.bmc.2008.06.051 | Unchecked | 2 |
| 18621536 | 10.1016/j.bmc.2008.06.051 | Nischarin | 2 |
| - | 10.1007/s00044-004-0023-9 | Unchecked | 1 |
| - | 10.1007/s00044-004-0023-9 | Nischarin | 1 |
| 27265687 | 10.1016/j.bmc.2016.05.043 | Nischarin | 1 |
Data from ChEMBL 36 via Core Engine