Assay Detail
Binding
CHEMBL3056381
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Binding affinity to I1 imidazoline binding site in Rattus norvegicus (rat) PC12 cells
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | PC-12 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Alpha2-Adrenergic Receptors in Intestinal Epithelial Cells: Mechanisms of Signaling, Role, and Regulation
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 7.24 | 10.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL360803 | PI-CLONIDINE | — | 1 | 10.47 |
| CHEMBL13881 | PHENAMAZOLINE | 2.0 | 1 | 9.30 |
| CHEMBL337862 | — | — | 1 | 9.03 |
| CHEMBL2092861 | — | — | 1 | 8.97 |
| CHEMBL266155 | BENAZOLINE | — | 1 | 8.89 |
| CHEMBL13789 | — | — | 1 | 8.63 |
| CHEMBL242265 | — | — | 1 | 8.40 |
| CHEMBL1162356 | — | — | 1 | 8.16 |
| CHEMBL289480 | RILMENIDINE | 4.0 | 1 | 7.95 |
| CHEMBL94022 | — | — | 1 | 7.93 |
| CHEMBL275970 | TRACIZOLINE | — | 1 | 7.73 |
| CHEMBL2261603 | — | — | 1 | 7.47 |
| CHEMBL134 | CLONIDINE | 4.0 | 1 | 6.95 |
| CHEMBL396013 | — | — | 1 | 6.89 |
| CHEMBL761 | NAPHAZOLINE | 4.0 | 1 | 6.61 |
| CHEMBL93845 | — | — | 1 | 6.46 |
| CHEMBL288951 | — | — | 1 | 6.29 |
| CHEMBL1907831 | — | — | 1 | 6.23 |
| CHEMBL14640 | — | — | 1 | 6.16 |
| CHEMBL13852 | CIRAZOLINE | 2.0 | 1 | 5.76 |
| CHEMBL416893 | — | — | 1 | 5.51 |
| CHEMBL501690 | — | — | 1 | 5.49 |
| CHEMBL14210 | PHENYZOLINE | — | 1 | 5.43 |
| CHEMBL1907832 | — | — | 1 | 5.20 |
| CHEMBL2092860 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL360803 | PI-CLONIDINE | Ki | = | 0.03388 | nM | 10.47 |
| CHEMBL13881 | PHENAMAZOLINE | Ki | = | 0.5012 | nM | 9.30 |
| CHEMBL337862 | — | Ki | = | 0.9333 | nM | 9.03 |
| CHEMBL2092861 | — | Ki | = | 1.072 | nM | 8.97 |
| CHEMBL266155 | BENAZOLINE | Ki | = | 1.288 | nM | 8.89 |
| CHEMBL13789 | — | Ki | = | 2.344 | nM | 8.63 |
| CHEMBL242265 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL1162356 | — | Ki | = | 6.918 | nM | 8.16 |
| CHEMBL289480 | RILMENIDINE | Ki | = | 11.22 | nM | 7.95 |
| CHEMBL94022 | — | Ki | = | 11.75 | nM | 7.93 |
| CHEMBL275970 | TRACIZOLINE | Ki | = | 18.62 | nM | 7.73 |
| CHEMBL2261603 | — | Ki | = | 33.88 | nM | 7.47 |
| CHEMBL134 | CLONIDINE | Ki | = | 112.2 | nM | 6.95 |
| CHEMBL396013 | — | Ki | = | 128.82 | nM | 6.89 |
| CHEMBL761 | NAPHAZOLINE | Ki | = | 245.47 | nM | 6.61 |
| CHEMBL93845 | — | Ki | = | 346.74 | nM | 6.46 |
| CHEMBL288951 | — | Ki | = | 512.86 | nM | 6.29 |
| CHEMBL1907831 | — | Ki | = | 588.84 | nM | 6.23 |
| CHEMBL14640 | — | Ki | = | 691.83 | nM | 6.16 |
| CHEMBL13852 | CIRAZOLINE | Ki | = | 1737.8 | nM | 5.76 |
| CHEMBL416893 | — | Ki | = | 3090.3 | nM | 5.51 |
| CHEMBL501690 | — | Ki | = | 3235.94 | nM | 5.49 |
| CHEMBL14210 | PHENYZOLINE | Ki | = | 3715.35 | nM | 5.43 |
| CHEMBL1907832 | — | Ki | = | 6309.57 | nM | 5.20 |
| CHEMBL2092860 | — | Ki | = | 7244.36 | nM | 5.14 |