Compound Detail
CHEMBL13881
PHENAMAZOLINE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL13881 |
| Name | PHENAMAZOLINE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | FPZTYKLEJPXTKD-UHFFFAOYSA-N |
5
Targets
7
Activities
1
Assay Types
0
PK Parameters
9
Publications
2
Known Names
Molecular Properties
175.2
MW (Da)
1.10
ALogP
3
HBA
2
HBD
36.4
PSA (Ų)
0.72
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Activity Summary
Ki 7 meas. best 9.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Nischarin CHEMBL5221 | Ki | 9.3 | 9.3 | 0.5 | 1 |
| Nischarin CHEMBL3923 | Ki | 7.5 | 7.5 | 31.6 | 1 |
| Monoamine oxidase CHEMBL2095205 | Ki | 7.48 | 7.48 | 33.1 | 1 |
| Unchecked CHEMBL612545 | Ki | 7.48 | 7.48 | 33.1 | 2 |
| Adrenergic receptor alpha-2 CHEMBL2093864 | Ki | 7.14 | 7.14 | 72.4 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Nischarin | Ki | = | 0.5012 | nM | 9.3 | Binding affinity to I1 imidazoline binding site in Rattus norvegicus (rat) PC12 ... | - |
| Nischarin | Ki | = | 31.62 | nM | 7.5 | Binding affinity for imidazoline receptor I-2 in rabbit kidney homogenate (relat... | 10737743 |
| Monoamine oxidase | Ki | = | 33.11 | nM | 7.48 | Displacement of [3H]idazoxan from imidazoline receptor I-2 binding sites in rabb... | 11754577 |
| Unchecked | Ki | = | 33.11 | nM | 7.48 | Binding affinity to I2 imidazoline binding site (unknown origin) | - |
| Unchecked | Ki | = | 33.11 | nM | 7.48 | Displacement of [3H]idazoxan from I2 receptor imidazoline binding site in rabbit... | 27774136 |
| Adrenergic receptor alpha-2 | Ki | = | 72.44 | nM | 7.14 | Displacement of [3H]clonidine from Alpha-2 adrenergic receptor of rat cortex mem... | 11754577 |
| Adrenergic receptor alpha-2 | Ki | = | 72.44 | nM | 7.14 | Displacement of [3H]-clonidine from alpha2-AR in rat brain cortical membranes af... | 27774136 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11754577 | 10.1021/jm0110082 | Adrenergic receptor alpha-2 | 2 |
| 10737743 | 10.1021/jm991124t | Nischarin | 1 |
| 11754577 | 10.1021/jm0110082 | Monoamine oxidase | 1 |
| 11754577 | 10.1021/jm0110082 | Adrenergic receptor alpha-1 | 1 |
| 11754577 | 10.1021/jm0110082 | Unchecked | 1 |
| - | 10.1007/s00044-004-0023-9 | Unchecked | 1 |
| - | 10.1007/s00044-004-0023-9 | Nischarin | 1 |
| 27774136 | 10.1021/acsmedchemlett.6b00290 | Unchecked | 1 |
| 27774136 | 10.1021/acsmedchemlett.6b00290 | Adrenergic receptor alpha-2 | 1 |
Data from ChEMBL 36 via Core Engine