Assay Detail
Binding
CHEMBL640225
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Displacement of [3H]clonidine from Alpha-2 adrenergic receptor of rat cortex membrane
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Alpha2-adrenoreceptors profile modulation and high antinociceptive activity of (S)-(-)-2-[1-(biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.09 | 7.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL128168 | BIPHENYLINE | — | 1 | 7.91 |
| CHEMBL396013 | — | — | 1 | 7.50 |
| CHEMBL337945 | — | — | 1 | 7.50 |
| CHEMBL14640 | — | — | 1 | 7.28 |
| CHEMBL13881 | PHENAMAZOLINE | 2.0 | 1 | 7.14 |
| CHEMBL13789 | — | — | 1 | 7.10 |
| CHEMBL273485 | — | — | 1 | 7.01 |
| CHEMBL242265 | — | — | 1 | 7.00 |
| CHEMBL130884 | — | — | 1 | 7.00 |
| CHEMBL131775 | — | — | 1 | 6.92 |
| CHEMBL131222 | — | — | 1 | 6.80 |
| CHEMBL13925 | — | — | 1 | 6.52 |
| CHEMBL337862 | — | — | 1 | 6.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL128168 | BIPHENYLINE | Ki | = | 12.3 | nM | 7.91 |
| CHEMBL396013 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL337945 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL14640 | — | Ki | = | 52.48 | nM | 7.28 |
| CHEMBL13881 | PHENAMAZOLINE | Ki | = | 72.44 | nM | 7.14 |
| CHEMBL13789 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL273485 | — | Ki | = | 97.72 | nM | 7.01 |
| CHEMBL242265 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL130884 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL131775 | — | Ki | = | 120.23 | nM | 6.92 |
| CHEMBL131222 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL13925 | — | Ki | = | 302.0 | nM | 6.52 |
| CHEMBL337862 | — | Ki | = | 354.81 | nM | 6.45 |