Assay Detail
Binding
CHEMBL3855981
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-clonidine from alpha2-AR in rat brain cortical membranes after 45 mins by liquid scintillation counting
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Combined Interactions with I1-, I2-Imidazoline Binding Sites and α2-Adrenoceptors To Manage Opioid Addiction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.14 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13881 | PHENAMAZOLINE | 2.0 | 1 | 7.14 |
| CHEMBL275970 | TRACIZOLINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13881 | PHENAMAZOLINE | Ki | = | 72.44 | nM | 7.14 |
| CHEMBL275970 | TRACIZOLINE | Ki | > | 1000.0 | nM | - |