Assay Detail
Binding
CHEMBL841870
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Displacement of [3H]idazoxan from imidazoline receptor I-2 binding sites in rabbit kidney membrane
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Kidney |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Alpha2-adrenoreceptors profile modulation and high antinociceptive activity of (S)-(-)-2-[1-(biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.15 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14640 | — | — | 1 | 9.05 |
| CHEMBL13881 | PHENAMAZOLINE | 2.0 | 1 | 7.48 |
| CHEMBL337945 | — | — | 1 | 6.74 |
| CHEMBL13925 | — | — | 1 | 6.70 |
| CHEMBL131775 | — | — | 1 | 6.57 |
| CHEMBL13789 | — | — | 1 | 6.52 |
| CHEMBL337862 | — | — | 1 | 6.09 |
| CHEMBL128168 | BIPHENYLINE | — | 1 | 5.79 |
| CHEMBL273485 | — | — | 1 | 5.57 |
| CHEMBL396013 | — | — | 1 | 5.14 |
| CHEMBL131222 | — | — | 1 | 5.12 |
| CHEMBL130884 | — | — | 1 | 4.90 |
| CHEMBL242265 | — | — | 1 | 4.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14640 | — | Ki | = | 0.8913 | nM | 9.05 |
| CHEMBL13881 | PHENAMAZOLINE | Ki | = | 33.11 | nM | 7.48 |
| CHEMBL337945 | — | Ki | = | 181.97 | nM | 6.74 |
| CHEMBL13925 | — | Ki | = | 199.53 | nM | 6.70 |
| CHEMBL131775 | — | Ki | = | 269.15 | nM | 6.57 |
| CHEMBL13789 | — | Ki | = | 302.0 | nM | 6.52 |
| CHEMBL337862 | — | Ki | = | 812.83 | nM | 6.09 |
| CHEMBL128168 | BIPHENYLINE | Ki | = | 1621.81 | nM | 5.79 |
| CHEMBL273485 | — | Ki | = | 2691.53 | nM | 5.57 |
| CHEMBL396013 | — | Ki | = | 7244.36 | nM | 5.14 |
| CHEMBL131222 | — | Ki | = | 7585.78 | nM | 5.12 |
| CHEMBL130884 | — | Ki | = | 12589.25 | nM | 4.90 |
| CHEMBL242265 | — | Ki | = | 48977.88 | nM | 4.31 |