Assay Detail
Binding
CHEMBL989165
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Displacement of [125I]PIC from human alpha2 adrenoceptors expressed in CHO cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
QSAR study of imidazoline antihypertensive drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.47 | 8.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL420 | GUANABENZ | 4.0 | 1 | 8.71 |
| CHEMBL1162356 | — | — | 1 | 8.53 |
| CHEMBL360803 | PI-CLONIDINE | — | 1 | 8.46 |
| CHEMBL134 | CLONIDINE | 4.0 | 1 | 7.78 |
| CHEMBL289480 | RILMENIDINE | 4.0 | 1 | 7.51 |
| CHEMBL597 | PHENTOLAMINE | 4.0 | 1 | 7.24 |
| CHEMBL57895 | EFAROXAN | 2.0 | 1 | 7.18 |
| CHEMBL10316 | IDAZOXAN | 3.0 | 1 | 7.05 |
| CHEMBL762 | OXYMETAZOLINE | 4.0 | 1 | 7.02 |
| CHEMBL1079 | TIZANIDINE | 4.0 | 1 | 6.93 |
| CHEMBL761 | NAPHAZOLINE | 4.0 | 1 | 6.83 |
| CHEMBL13852 | CIRAZOLINE | 2.0 | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL420 | GUANABENZ | Ki | = | 1.933 | nM | 8.71 |
| CHEMBL1162356 | — | Ki | = | 2.934 | nM | 8.53 |
| CHEMBL360803 | PI-CLONIDINE | Ki | = | 3.467 | nM | 8.46 |
| CHEMBL134 | CLONIDINE | Ki | = | 16.5 | nM | 7.78 |
| CHEMBL289480 | RILMENIDINE | Ki | = | 30.54 | nM | 7.51 |
| CHEMBL597 | PHENTOLAMINE | Ki | = | 57.03 | nM | 7.24 |
| CHEMBL57895 | EFAROXAN | Ki | = | 65.9 | nM | 7.18 |
| CHEMBL10316 | IDAZOXAN | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL762 | OXYMETAZOLINE | Ki | = | 94.62 | nM | 7.02 |
| CHEMBL1079 | TIZANIDINE | Ki | = | 117.9 | nM | 6.93 |
| CHEMBL761 | NAPHAZOLINE | Ki | = | 147.1 | nM | 6.83 |
| CHEMBL13852 | CIRAZOLINE | Ki | = | 384.33 | nM | 6.42 |