Compound Detail
CHEMBL10316
IDAZOXAN 🧪 Phase III
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🧪 Phase III
Basic Information
| ChEMBL ID | CHEMBL10316 |
| Name | IDAZOXAN |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | HPMRFMKYPGXPEP-UHFFFAOYSA-N |
18
Targets
87
Activities
3
Assay Types
5
PK Parameters
20
Publications
6
Known Names
2
Indications
1
Mechanisms
Molecular Properties
204.2
MW (Da)
0.83
ALogP
4
HBA
1
HBD
42.9
PSA (Ų)
0.74
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Racemic |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Adrenergic receptor alpha-2 antagonist | ANTAGONIST | Adrenergic receptor alpha-2 | ✓ | ✓ |
Indications
Depressive Disorder, Major Alzheimer Disease
Activity Summary
Ki 46 meas. best 8.82
Kd 29 meas. best 8.64
IC50 12 meas. best 8.08
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Alpha-2A adrenergic receptor CHEMBL4744 | Ki | 8.82 | 8.82 | 1.5 | 1 |
| Adrenergic receptor alpha-2 CHEMBL2093864 | Ki | 8.76 | 8.095 | 1.7 | 8 |
| Adrenergic receptor alpha-2 CHEMBL2093864 | Kd | 8.64 | 8.0869 | 2.3 | 13 |
| Cavia porcellus CHEMBL369 | Kd | 8.4 | 8.4 | 4.0 | 1 |
| Adrenergic receptor alpha-2 CHEMBL2095158 | Kd | 8.4 | 7.6967 | 4.0 | 3 |
| Unchecked CHEMBL612545 | Ki | 8.37 | 7.2633 | 4.3 | 12 |
| Adrenergic receptor alpha-2 CHEMBL2095158 | Ki | 8.35 | 7.6433 | 4.5 | 3 |
| Alpha-2A adrenergic receptor CHEMBL1867 | Ki | 8.15 | 8.1333 | 7.1 | 3 |
| Nischarin CHEMBL3923 | Ki | 8.1 | 6.605 | 7.9 | 4 |
| Alpha-2A adrenergic receptor CHEMBL1867 | IC50 | 8.08 | 8.08 | 8.3 | 1 |
| Rattus norvegicus CHEMBL376 | Kd | 7.98 | 7.98 | 10.5 | 1 |
| Unchecked CHEMBL612545 | IC50 | 7.92 | 7.92 | 12.0 | 1 |
| Alpha-2C adrenergic receptor CHEMBL1916 | Ki | 7.75 | 7.74 | 17.8 | 3 |
| Alpha-2B adrenergic receptor CHEMBL1942 | IC50 | 7.71 | 7.71 | 19.5 | 1 |
| Adrenergic receptor alpha-2 CHEMBL2093864 | IC50 | 7.68 | 7.68 | 21.0 | 1 |
| Alpha-2B adrenergic receptor CHEMBL1942 | Ki | 7.64 | 7.4267 | 22.9 | 3 |
| Monoamine oxidase CHEMBL2095205 | Ki | 7.55 | 7.55 | 28.0 | 1 |
| Alpha-2C adrenergic receptor CHEMBL1916 | IC50 | 7.27 | 7.27 | 53.7 | 1 |
| Adrenergic receptor alpha-1 CHEMBL2094251 | Kd | 6.85 | 6.85 | 141.2 | 1 |
| Adrenergic receptor alpha-1 CHEMBL1907610 | Ki | 6.58 | 6.2917 | 261.0 | 6 |
| Adrenergic receptor alpha-1 CHEMBL1907610 | Kd | 6.57 | 6.221 | 269.1 | 10 |
| Alpha-1A adrenergic receptor CHEMBL4892 | Ki | 6.3 | 6.3 | 500.0 | 1 |
| Amine oxidase [flavin-containing] A CHEMBL1951 | IC50 | 6.0 | 6.0 | 1000.0 | 2 |
| Amine oxidase [flavin-containing] B CHEMBL2039 | IC50 | 6.0 | 6.0 | 1000.0 | 2 |
| Nischarin CHEMBL5221 | Ki | 5.9 | 5.9 | 1258.9 | 1 |
| Adrenergic receptor alpha-1 CHEMBL1907610 | IC50 | 5.78 | 5.78 | 1650.0 | 1 |
| Alpha-1A adrenergic receptor CHEMBL229 | IC50 | 5.54 | 5.54 | 2884.0 | 1 |
| Rattus norvegicus CHEMBL376 | IC50 | 4.89 | 4.89 | 13000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 10.0 | mL.min-1.kg-1 | Homo sapiens |
| CL | 10.0 | mL.min-1.kg-1 | Homo sapiens |
| CL | 10.0 | mL.min-1.kg-1 | Homo sapiens |
| MRT | 5.5 | hr | Homo sapiens |
| T1/2 | 4.2 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine