Assay Detail
Functional
CHEMBL689682
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro reversal of inhibitory effect of UK - 14304 on the contractile response of guinea pig ileum to field stimulation.
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-affinity relationships of 12-sulfonyl derivatives of 5,8,8a,9,10,11,12,12a,13,13a-decahydro-6H-isoquino[2,1-g][1 ,6] naphthyridines at alpha-adrenoceptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 11 | 8.86 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL163911 | DELEQUAMINE | 2.0 | 1 | 9.70 |
| CHEMBL279807 | — | — | 1 | 9.70 |
| CHEMBL352278 | — | — | 1 | 9.50 |
| CHEMBL355140 | — | — | 1 | 9.40 |
| CHEMBL164420 | — | — | 1 | 9.30 |
| CHEMBL162971 | — | — | 1 | 9.00 |
| CHEMBL411954 | — | — | 1 | 8.90 |
| CHEMBL349665 | — | — | 1 | 8.80 |
| CHEMBL10316 | IDAZOXAN | 3.0 | 1 | 8.40 |
| CHEMBL163290 | — | — | 1 | 8.30 |
| CHEMBL163489 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL163911 | DELEQUAMINE | Kd | = | 0.1995 | nM | 9.70 |
| CHEMBL279807 | — | Kd | = | 0.1995 | nM | 9.70 |
| CHEMBL352278 | — | Kd | = | 0.3162 | nM | 9.50 |
| CHEMBL355140 | — | Kd | = | 0.3981 | nM | 9.40 |
| CHEMBL164420 | — | Kd | = | 0.5012 | nM | 9.30 |
| CHEMBL162971 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL411954 | — | Kd | = | 1.259 | nM | 8.90 |
| CHEMBL349665 | — | Kd | = | 1.585 | nM | 8.80 |
| CHEMBL10316 | IDAZOXAN | Kd | = | 3.981 | nM | 8.40 |
| CHEMBL163290 | — | Kd | = | 5.012 | nM | 8.30 |
| CHEMBL163489 | — | Kd | = | 316.23 | nM | 6.50 |