Assay Detail
Functional
CHEMBL641538
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity against presynaptic alpha-2 adrenergic receptor in isolated rat vas deferens using xylazine as agonist
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Vas deferens |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Berbanes: a new class of selective alpha 2-adrenoceptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 23 | 6.78 | 8.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL28531 | — | — | 1 | 8.17 |
| CHEMBL10316 | IDAZOXAN | 3.0 | 1 | 8.07 |
| CHEMBL597 | PHENTOLAMINE | 4.0 | 1 | 7.78 |
| CHEMBL15245 | YOHIMBINE | 3.0 | 1 | 7.72 |
| CHEMBL29379 | — | — | 1 | 7.63 |
| CHEMBL282636 | — | — | 1 | 7.41 |
| CHEMBL25979 | — | — | 1 | 7.39 |
| CHEMBL29869 | — | — | 1 | 7.30 |
| CHEMBL281708 | — | — | 1 | 7.18 |
| CHEMBL26156 | — | — | 1 | 7.12 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 6.84 |
| CHEMBL280650 | — | — | 1 | 6.77 |
| CHEMBL280810 | — | — | 1 | 6.61 |
| CHEMBL424034 | — | — | 1 | 6.41 |
| CHEMBL416757 | — | — | 1 | 6.31 |
| CHEMBL27522 | — | — | 1 | 6.21 |
| CHEMBL283875 | — | — | 1 | 6.21 |
| CHEMBL286033 | — | — | 1 | 6.10 |
| CHEMBL30114 | — | — | 1 | 5.91 |
| CHEMBL25982 | — | — | 1 | 5.80 |
| CHEMBL27355 | — | — | 1 | 5.74 |
| CHEMBL26421 | — | — | 1 | 5.64 |
| CHEMBL29380 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL28531 | — | Kd | = | 6.761 | nM | 8.17 |
| CHEMBL10316 | IDAZOXAN | Kd | = | 8.511 | nM | 8.07 |
| CHEMBL597 | PHENTOLAMINE | Kd | = | 16.6 | nM | 7.78 |
| CHEMBL15245 | YOHIMBINE | Kd | = | 19.05 | nM | 7.72 |
| CHEMBL29379 | — | Kd | = | 23.44 | nM | 7.63 |
| CHEMBL282636 | — | Kd | = | 38.9 | nM | 7.41 |
| CHEMBL25979 | — | Kd | = | 40.74 | nM | 7.39 |
| CHEMBL29869 | — | Kd | = | 50.12 | nM | 7.30 |
| CHEMBL281708 | — | Kd | = | 66.07 | nM | 7.18 |
| CHEMBL26156 | — | Kd | = | 75.86 | nM | 7.12 |
| CHEMBL2 | PRAZOSIN | Kd | = | 144.54 | nM | 6.84 |
| CHEMBL280650 | — | Kd | = | 169.82 | nM | 6.77 |
| CHEMBL280810 | — | Kd | = | 245.47 | nM | 6.61 |
| CHEMBL424034 | — | Kd | = | 389.05 | nM | 6.41 |
| CHEMBL416757 | — | Kd | = | 489.78 | nM | 6.31 |
| CHEMBL27522 | — | Kd | = | 616.6 | nM | 6.21 |
| CHEMBL283875 | — | Kd | = | 616.6 | nM | 6.21 |
| CHEMBL286033 | — | Kd | = | 794.33 | nM | 6.10 |
| CHEMBL30114 | — | Kd | = | 1230.27 | nM | 5.91 |
| CHEMBL25982 | — | Kd | = | 1584.89 | nM | 5.80 |
| CHEMBL27355 | — | Kd | = | 1819.7 | nM | 5.74 |
| CHEMBL26421 | — | Kd | = | 2290.87 | nM | 5.64 |
| CHEMBL29380 | — | Kd | = | 2511.89 | nM | 5.60 |