Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL30114

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
OC[C@@H]1C[C@@H]2CN3CCc4cc5c(cc4[C@@H]3C[C@@H]2C[C@@H]1O)OCO5

Basic Information

ChEMBL ID CHEMBL30114
Phase Preclinical
Structure Type MOL
InChI Key QPXWXQBSYHMBFC-BJMQQELFSA-N
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

331.4
MW (Da)
1.71
ALogP
5
HBA
2
HBD
62.2
PSA (Ų)
0.82
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H25NO4
MW 331.41
Aromatic Rings 1
Heavy Atoms 24
NP-Likeness 1.53

Activity Summary

Kd 3 meas. best 6.51

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adrenergic receptor alpha-2
CHEMBL2095158
Kd 6.51 6.51 309.0 1
Adrenergic receptor alpha-2
CHEMBL2093864
Kd 6.3 6.105 501.2 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
2886664 10.1021/jm00391a015 Adrenergic receptor alpha-2 3
2886664 10.1021/jm00391a015 Adrenergic receptor alpha-1 1
2886664 10.1021/jm00391a015 Adrenergic receptor alpha 1

Data from ChEMBL 36 via Core Engine