Assay Detail
Binding
CHEMBL903398
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HT-29 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Novel 4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)methylbenzofuran derivatives as selective alpha(2C)-adrenergic receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 6.77 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL537669 | YOHIMBINE HYDROCHLORIDE | 3.0 | 1 | 8.74 |
| CHEMBL10316 | IDAZOXAN | 3.0 | 1 | 8.10 |
| CHEMBL394218 | — | — | 1 | 7.38 |
| CHEMBL246229 | — | — | 1 | 6.87 |
| CHEMBL247664 | — | — | 1 | 6.85 |
| CHEMBL247665 | — | — | 1 | 6.73 |
| CHEMBL392991 | — | — | 1 | 6.69 |
| CHEMBL392771 | — | — | 1 | 6.67 |
| CHEMBL246852 | — | — | 1 | 6.52 |
| CHEMBL246228 | — | — | 1 | 6.40 |
| CHEMBL428407 | — | — | 1 | 6.34 |
| CHEMBL393597 | — | — | 1 | 6.07 |
| CHEMBL392992 | — | — | 1 | 5.76 |
| CHEMBL246639 | — | — | 1 | 5.59 |
| CHEMBL246434 | — | — | 1 | - |
| CHEMBL246435 | — | — | 1 | - |
| CHEMBL438123 | — | — | 1 | - |
| CHEMBL247467 | — | — | 1 | - |
| CHEMBL247466 | — | — | 1 | - |
| CHEMBL247057 | — | — | 1 | - |
| CHEMBL247056 | — | — | 1 | - |
| CHEMBL393783 | — | — | 1 | - |
| CHEMBL246851 | — | — | 1 | - |
| CHEMBL246640 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL537669 | YOHIMBINE HYDROCHLORIDE | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL10316 | IDAZOXAN | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL394218 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL246229 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL247664 | — | Ki | = | 141.0 | nM | 6.85 |
| CHEMBL247665 | — | Ki | = | 186.0 | nM | 6.73 |
| CHEMBL392991 | — | Ki | = | 204.0 | nM | 6.69 |
| CHEMBL392771 | — | Ki | = | 216.0 | nM | 6.67 |
| CHEMBL246852 | — | Ki | = | 304.0 | nM | 6.52 |
| CHEMBL246228 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL428407 | — | Ki | = | 454.0 | nM | 6.34 |
| CHEMBL393597 | — | Ki | = | 857.0 | nM | 6.07 |
| CHEMBL392992 | — | Ki | = | 1742.0 | nM | 5.76 |
| CHEMBL246639 | — | Ki | = | 2552.0 | nM | 5.59 |
| CHEMBL246434 | — | Ki | - | — | - | |
| CHEMBL246435 | — | Ki | - | — | - | |
| CHEMBL438123 | — | Ki | - | — | - | |
| CHEMBL247467 | — | Ki | - | — | - | |
| CHEMBL247466 | — | Ki | - | — | - | |
| CHEMBL247057 | — | Ki | - | — | - | |
| CHEMBL247056 | — | Ki | - | — | - | |
| CHEMBL393783 | — | Ki | - | — | - | |
| CHEMBL246851 | — | Ki | - | — | - | |
| CHEMBL246640 | — | Ki | - | — | - |