Compound Detail
CHEMBL393597
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL393597 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NTHIAFXFYRUEJP-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
447.5
MW (Da)
5.82
ALogP
5
HBA
0
HBD
44.1
PSA (Ų)
0.37
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 7.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Alpha-2C adrenergic receptor CHEMBL1916 | Ki | 7.96 | 7.96 | 11.0 | 1 |
| Alpha-2B adrenergic receptor CHEMBL1942 | Ki | 6.52 | 6.52 | 299.0 | 1 |
| Alpha-2A adrenergic receptor CHEMBL1867 | Ki | 6.07 | 6.07 | 857.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Alpha-2C adrenergic receptor | Ki | = | 11.0 | nM | 7.96 | Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells | 17257841 |
| Alpha-2B adrenergic receptor | Ki | = | 299.0 | nM | 6.52 | Displacement of [3H]MK912 from adrenergic alpha-2B receptor expressed in COS7 ce... | 17257841 |
| Alpha-2A adrenergic receptor | Ki | = | 857.0 | nM | 6.07 | Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells | 17257841 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17257841 | 10.1016/j.bmcl.2006.12.094 | Alpha-2A adrenergic receptor | 1 |
| 17257841 | 10.1016/j.bmcl.2006.12.094 | Alpha-2B adrenergic receptor | 1 |
| 17257841 | 10.1016/j.bmcl.2006.12.094 | Alpha-2C adrenergic receptor | 1 |
Data from ChEMBL 36 via Core Engine