Assay Detail
Binding
CHEMBL649633
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity at Alpha-2 adrenergic receptor in rat cortex by radioligand binding assay using [3H]rauwolscine
8
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological characterization of ABT-200: a putative novel antidepressant combining potent -2 antagonism with moderate NE uptake inhibition
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.64 | 9.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27926 | NAPITANE | 2.0 | 3 | 9.37 |
| CHEMBL25014 | — | — | 1 | 9.30 |
| CHEMBL10316 | IDAZOXAN | 3.0 | 1 | 8.76 |
| CHEMBL285367 | — | — | 1 | 8.68 |
| CHEMBL433033 | — | — | 1 | 8.34 |
| CHEMBL11 | IMIPRAMINE | 4.0 | 1 | 6.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27926 | NAPITANE | Ki | = | 0.428 | nM | 9.37 |
| CHEMBL25014 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL27926 | NAPITANE | Ki | = | 0.708 | nM | 9.15 |
| CHEMBL27926 | NAPITANE | Ki | = | 1.23 | nM | 8.91 |
| CHEMBL10316 | IDAZOXAN | Ki | = | 1.72 | nM | 8.76 |
| CHEMBL285367 | — | Ki | = | 2.08 | nM | 8.68 |
| CHEMBL433033 | — | Ki | = | 4.56 | nM | 8.34 |
| CHEMBL11 | IMIPRAMINE | Ki | = | 255.0 | nM | 6.59 |