Skip to main content
Free research Free research Free target review with research home and workspace preview
Quick search ChEMBL 36
Loading Target Snapshot...
Querying ChEMBL database. This may take a few seconds.
Target Snapshot

CHEMBL4744 Target Snapshot

Alpha-2A adrenergic receptor · SINGLE PROTEIN · Bos taurus

Back to Search Search this target Browse approvals Evidence Card
133Compounds
18Assays
6Approved Drugs
152.0Activities
Free Research Context

Research home keeps recent targets

This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.

Research home Demo workspace
Navigation

Switch target

Move to another high-traffic target or paste a specific ChEMBL target ID.

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q28838. Use UniProt Q28838 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q28838 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Alpha-2A adrenergic receptor as ChEMBL target CHEMBL4744, mapped to UniProt Q28838. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Alpha-2A adrenergic receptor
SINGLE PROTEIN · Bos taurus
As of 2026-09-13
ChEMBL target ID
CHEMBL4744
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q28838
Alpha-2A adrenergic receptor
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Alpha-2A adrenergic receptor is the right protein anchor across sources, using UniProt Q28838 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameAlpha-2A adrenergic receptor
Target TypeSINGLE PROTEIN
OrganismBos taurus
UniProtQ28838
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelAlpha-2A adrenergic receptor
UniProt AccessionQ28838
Component TypeProtein
Sequence Length468 aa

Alpha-2A adrenergic receptor

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Alpha-2A adrenergic receptor, mapped to UniProt Q28838. Sequence length is 468 aa.

Mapped IDQ28838
Review nameAlpha-2A adrenergic receptor
OrganismBos taurus
Clinical Profile

Clinical Phase Distribution

6
Approved
2
Phase III
1
Phase II
Assay Mix

Activity Type Distribution

IC5058.0
KI94.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL48603 9.11 Ki 0.77 Preclinical
CHEMBL597 9.03 Ki 0.93 Approved
CHEMBL48558 8.87 Ki 1.36 Preclinical
CHEMBL10316 8.82 Ki 1.5 Clinical
CHEMBL762 8.82 Ki 1.5 Approved
CHEMBL51358 8.74 Ki 1.8 Preclinical
CHEMBL51131 8.74 Ki 1.8 Preclinical
CHEMBL134 8.7 IC50 2.0 Approved
CHEMBL47415 8.57 Ki 2.7 Preclinical
CHEMBL50017 8.54 Ki 2.9 Preclinical
Distribution

pChEMBL Value Distribution

22
5.0
16
5.5
29
6.0
20
6.5
20
7.0
14
7.5
9
8.0
9
8.5
2
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

OXYMETAZOLINE
CHEMBL762
Approved 1986
Properties Compare Identifier
PRAZOSIN
CHEMBL2
Approved 1976
Properties Compare Identifier
CLONIDINE
CHEMBL134
Approved 1974
Properties Compare Identifier
PHENTOLAMINE
CHEMBL597
Approved 1952
Properties Compare Identifier
MIANSERIN
CHEMBL6437
Properties Compare Identifier
Assay Landscape

Assay Landscape

18
Total Assays
131
Tested Compounds
1
Assay Types
Binding — 18 assays, 131 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 10 106 6.5
single protein format 6 25 6.9
assay format 2 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine