Assay Detail
Functional
CHEMBL816960
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In vitro antagonistic activity against alpha-2 adrenergic receptor in isolated electrically stimulated rat vas deferens (clonidine-induced decrease in twitch height)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Vas deferens |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and antidepressant properties of novel 2-substituted 4,5-dihydro-1H-imidazole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 12 | 7.44 | 8.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10316 | IDAZOXAN | 3.0 | 1 | 8.11 |
| CHEMBL15245 | YOHIMBINE | 3.0 | 1 | 7.91 |
| CHEMBL553031 | NAPAMEZOLE HYDROCHLORIDE | -1.0 | 1 | 7.76 |
| CHEMBL545647 | — | — | 1 | 7.71 |
| CHEMBL544001 | — | — | 1 | 7.67 |
| CHEMBL553439 | — | — | 1 | 7.43 |
| CHEMBL559829 | — | — | 1 | 7.35 |
| CHEMBL544706 | — | — | 1 | 7.22 |
| CHEMBL544701 | — | — | 1 | 7.19 |
| CHEMBL545646 | — | — | 1 | 7.19 |
| CHEMBL35345 | — | — | 1 | 6.92 |
| CHEMBL6437 | MIANSERIN | 4.0 | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10316 | IDAZOXAN | Kd | = | 7.762 | nM | 8.11 |
| CHEMBL15245 | YOHIMBINE | Kd | = | 12.3 | nM | 7.91 |
| CHEMBL553031 | NAPAMEZOLE HYDROCHLORIDE | Kd | = | 17.38 | nM | 7.76 |
| CHEMBL545647 | — | Kd | = | 19.5 | nM | 7.71 |
| CHEMBL544001 | — | Kd | = | 21.38 | nM | 7.67 |
| CHEMBL553439 | — | Kd | = | 37.15 | nM | 7.43 |
| CHEMBL559829 | — | Kd | = | 44.67 | nM | 7.35 |
| CHEMBL544706 | — | Kd | = | 60.26 | nM | 7.22 |
| CHEMBL544701 | — | Kd | = | 64.57 | nM | 7.19 |
| CHEMBL545646 | — | Kd | = | 64.57 | nM | 7.19 |
| CHEMBL35345 | — | Kd | = | 120.23 | nM | 6.92 |
| CHEMBL6437 | MIANSERIN | Kd | = | 158.49 | nM | 6.80 |