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Compound Detail

CHEMBL35345

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CC1=C(Cc2ncc[nH]2)CCc2ccccc21

Basic Information

ChEMBL ID CHEMBL35345
Phase Preclinical
Structure Type MOL
InChI Key ZDEZZEXVRHVGGC-UHFFFAOYSA-N
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

224.3
MW (Da)
3.37
ALogP
1
HBA
1
HBD
28.7
PSA (Ų)
0.83
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H16N2
MW 224.31
Aromatic Rings 2
Heavy Atoms 17
NP-Likeness -0.36

Activity Summary

Kd 1 meas. best 6.92
Ki 1 meas. best 7.06

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adrenergic receptor alpha-2
CHEMBL2093864
Ki 7.06 7.06 88.0 1
Adrenergic receptor alpha-2
CHEMBL2093864
Kd 6.92 6.92 120.2 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
3039138 10.1021/jm00391a034 Adrenergic receptor alpha-2 2

Data from ChEMBL 36 via Core Engine