Assay Detail
Binding
CHEMBL816957
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to displace [3H]clonidine from alpha-2 adrenergic receptor in rat brain homogenates in vitro
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and antidepressant properties of novel 2-substituted 4,5-dihydro-1H-imidazole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.22 | 8.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL559829 | — | — | 1 | 8.18 |
| CHEMBL545647 | — | — | 1 | 8.16 |
| CHEMBL10316 | IDAZOXAN | 3.0 | 1 | 8.00 |
| CHEMBL545646 | — | — | 1 | 7.92 |
| CHEMBL553031 | NAPAMEZOLE HYDROCHLORIDE | -1.0 | 1 | 7.64 |
| CHEMBL553439 | — | — | 1 | 7.50 |
| CHEMBL544001 | — | — | 1 | 7.32 |
| CHEMBL544701 | — | — | 1 | 7.12 |
| CHEMBL6437 | MIANSERIN | 4.0 | 1 | 7.12 |
| CHEMBL15245 | YOHIMBINE | 3.0 | 1 | 7.11 |
| CHEMBL35345 | — | — | 1 | 7.06 |
| CHEMBL544706 | — | — | 1 | 6.87 |
| CHEMBL544704 | — | — | 1 | 6.48 |
| CHEMBL544705 | — | — | 1 | 6.40 |
| CHEMBL553103 | — | — | 1 | 6.36 |
| CHEMBL553368 | — | — | 1 | 6.26 |
| CHEMBL543535 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL559829 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL545647 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL10316 | IDAZOXAN | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL545646 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL553031 | NAPAMEZOLE HYDROCHLORIDE | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL553439 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL544001 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL544701 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL6437 | MIANSERIN | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL15245 | YOHIMBINE | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL35345 | — | Ki | = | 88.0 | nM | 7.06 |
| CHEMBL544706 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL544704 | — | Ki | = | 334.0 | nM | 6.48 |
| CHEMBL544705 | — | Ki | = | 401.0 | nM | 6.40 |
| CHEMBL553103 | — | Ki | = | 436.0 | nM | 6.36 |
| CHEMBL553368 | — | Ki | = | 548.0 | nM | 6.26 |
| CHEMBL543535 | — | Ki | > | 800.0 | nM | - |