Assay Detail
Functional
CHEMBL641534
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Antagonist potency towards alpha-2 adrenergic receptor in the rat electrically stimulated vas deferens with reference to P-aminoclonidine
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Vas deferens |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Effect of methoxy substitution on the adrenergic activity of three structurally related alpha 2-adrenoreceptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 7.74 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10332 | — | — | 1 | 9.92 |
| CHEMBL10316 | IDAZOXAN | 3.0 | 1 | 8.29 |
| CHEMBL31836 | PIPEROXAN | 2.0 | 1 | 7.54 |
| CHEMBL52429 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10332 | — | Kd | = | 0.1202 | nM | 9.92 |
| CHEMBL10316 | IDAZOXAN | Kd | = | 5.129 | nM | 8.29 |
| CHEMBL31836 | PIPEROXAN | Kd | = | 28.84 | nM | 7.54 |
| CHEMBL52429 | — | Kd | = | 6456.54 | nM | 5.19 |