Assay Detail
Binding
CHEMBL643221
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Alpha-2 adrenergic receptor pA2 value against clonidine in vitro experiment in rat vas deferens
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Vas deferens |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
alpha-adrenoreceptor reagents. 1. Synthesis of some 1,4-benzodioxans as selective presynaptic alpha 2-adrenoreceptor antagonists and potential antidepressants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 7.77 | 8.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10316 | IDAZOXAN | 3.0 | 1 | 8.56 |
| CHEMBL347695 | IMILOXAN | 2.0 | 1 | 6.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10316 | IDAZOXAN | Kd | = | 2.754 | nM | 8.56 |
| CHEMBL347695 | IMILOXAN | Kd | = | 104.71 | nM | 6.98 |