Assay Detail

CHEMBL1959317

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Binding affinity to I2 imidazoline binding site

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Favourable involvement of α2A-adrenoreceptor antagonism in the I₂-imidazoline binding sites-mediated morphine analgesia enhancement.

Mammoli V, Bonifazi A, Del Bello F, Diamanti E, Giannella M, Hudson AL, Mattioli L, Perfumi M, Piergentili A, Quaglia W, Titomanlio F, Pigini M.
Bioorg Med Chem (2012) 20 : 2259 -2265
PubMed 22370341 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	2	8.49	8.60

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL14210	PHENYZOLINE	—	1	8.60
CHEMBL10316	IDAZOXAN	3.0	1	8.37

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL14210	PHENYZOLINE	Ki	=	2.512	nM	8.60
CHEMBL10316	IDAZOXAN	Ki	=	4.266	nM	8.37