Assay Detail
Functional
CHEMBL687415
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to reverse inhibitory effects of UK-14304 on the contraction of guinea pig ileum as a measure of alpha-2 adrenergic receptor antagonism.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
(8a alpha,12a alpha,13a alpha)-5,8,8a,9,10,11,12,12a,13,13a-decahydro- 3-methoxy-12-(methylsulfonyl)-6H-isoquino[2,1-g][1,6]naphthyridi ne, a potent and highly selective alpha 2-adrenoceptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 8.58 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279807 | — | — | 1 | 9.70 |
| CHEMBL62912 | — | — | 1 | 9.70 |
| CHEMBL10316 | IDAZOXAN | 3.0 | 1 | 8.40 |
| CHEMBL62833 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279807 | — | Kd | = | 0.1995 | nM | 9.70 |
| CHEMBL62912 | — | Kd | = | 0.1995 | nM | 9.70 |
| CHEMBL10316 | IDAZOXAN | Kd | = | 3.981 | nM | 8.40 |
| CHEMBL62833 | — | Kd | = | 316.23 | nM | 6.50 |