Assay Detail
Functional
CHEMBL642135
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Alpha-2 adrenergic receptor antagonistic activity in rat vas deferens vs clonidin
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Vas deferens |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Alpha 2-adrenergic agonists/antagonists: the synthesis and structure-activity relationships of a series of indolin-2-yl and tetrahydroquinolin-2-yl imidazolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 15 | 7.90 | 8.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL36616 | — | — | 1 | 8.91 |
| CHEMBL38788 | — | — | 1 | 8.76 |
| CHEMBL38829 | — | — | 1 | 8.65 |
| CHEMBL39254 | — | — | 1 | 8.56 |
| CHEMBL41720 | — | — | 1 | 8.45 |
| CHEMBL38406 | — | — | 1 | 8.13 |
| CHEMBL10316 | IDAZOXAN | 3.0 | 1 | 8.11 |
| CHEMBL37352 | — | — | 1 | 8.03 |
| CHEMBL41861 | — | — | 1 | 8.00 |
| CHEMBL289153 | — | — | 1 | 7.93 |
| CHEMBL289098 | — | — | 1 | 7.59 |
| CHEMBL41803 | — | — | 1 | 6.96 |
| CHEMBL288337 | — | — | 1 | 6.60 |
| CHEMBL38790 | — | — | 1 | 5.88 |
| CHEMBL41305 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL36616 | — | Kd | = | 1.23 | nM | 8.91 |
| CHEMBL38788 | — | Kd | = | 1.738 | nM | 8.76 |
| CHEMBL38829 | — | Kd | = | 2.239 | nM | 8.65 |
| CHEMBL39254 | — | Kd | = | 2.754 | nM | 8.56 |
| CHEMBL41720 | — | Kd | = | 3.548 | nM | 8.45 |
| CHEMBL38406 | — | Kd | = | 7.413 | nM | 8.13 |
| CHEMBL10316 | IDAZOXAN | Kd | = | 7.762 | nM | 8.11 |
| CHEMBL37352 | — | Kd | = | 9.333 | nM | 8.03 |
| CHEMBL41861 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL289153 | — | Kd | = | 11.75 | nM | 7.93 |
| CHEMBL289098 | — | Kd | = | 25.7 | nM | 7.59 |
| CHEMBL41803 | — | Kd | = | 109.65 | nM | 6.96 |
| CHEMBL288337 | — | Kd | = | 251.19 | nM | 6.60 |
| CHEMBL38790 | — | Kd | = | 1318.26 | nM | 5.88 |
| CHEMBL41305 | — | Kd | > | 1000.0 | nM | - |