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Compound Detail

CHEMBL288337

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CCC[C@@]1(C2=NCCN2)Cc2ccccc2N1C

Basic Information

ChEMBL ID CHEMBL288337
Phase Preclinical
Structure Type MOL
InChI Key ZEPAHEKGBKBPLS-HNNXBMFYSA-N
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

243.3
MW (Da)
2.22
ALogP
3
HBA
1
HBD
27.6
PSA (Ų)
0.88
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H21N3
MW 243.35
Aromatic Rings 1
Heavy Atoms 18
NP-Likeness 0.24

Activity Summary

Kd 1 meas. best 6.6
Ki 1 meas. best 6.58

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adrenergic receptor alpha-2
CHEMBL2093864
Kd 6.6 6.6 251.2 1
Adrenergic receptor alpha-2
CHEMBL2093864
Ki 6.58 6.58 260.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
2887657 10.1021/jm00392a005 Adrenergic receptor alpha-2 3
2887657 10.1021/jm00392a005 Mus musculus 1

Data from ChEMBL 36 via Core Engine