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Compound Detail

CHEMBL39254

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CN1c2ccc(Cl)cc2CC1C1=NCCN1

Basic Information

ChEMBL ID CHEMBL39254
Phase Preclinical
Structure Type MOL
InChI Key AMGRNYFVUYGWDC-UHFFFAOYSA-N
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

235.7
MW (Da)
1.70
ALogP
3
HBA
1
HBD
27.6
PSA (Ų)
0.80
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C12H14ClN3
MW 235.72
Aromatic Rings 1
Heavy Atoms 16
NP-Likeness -0.47

Activity Summary

Kd 1 meas. best 8.56
Ki 1 meas. best 8.72

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adrenergic receptor alpha-2
CHEMBL2093864
Ki 8.72 8.72 1.9 1
Adrenergic receptor alpha-2
CHEMBL2093864
Kd 8.56 8.56 2.8 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
2896247 10.1021/jm00400a009 Rattus norvegicus 4
2896247 10.1021/jm00400a009 Adrenergic receptor alpha-1 2
2896247 10.1021/jm00400a009 Adrenergic receptor alpha-2 2
2887657 10.1021/jm00392a005 Adrenergic receptor alpha-2 2
2887657 10.1021/jm00392a005 Mus musculus 1

Data from ChEMBL 36 via Core Engine