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Compound Detail

CHEMBL289098

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CN1c2ccc(Cc3ccccc3)cc2CC1C1=NCCN1

Basic Information

ChEMBL ID CHEMBL289098
Phase Preclinical
Structure Type MOL
InChI Key MOWFPZYDKQXMAE-UHFFFAOYSA-N
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

291.4
MW (Da)
2.64
ALogP
3
HBA
1
HBD
27.6
PSA (Ų)
0.94
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H21N3
MW 291.40
Aromatic Rings 2
Heavy Atoms 22
NP-Likeness -0.08

Activity Summary

Kd 1 meas. best 7.59
Ki 1 meas. best 7.27

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adrenergic receptor alpha-2
CHEMBL2093864
Kd 7.59 7.59 25.7 1
Adrenergic receptor alpha-2
CHEMBL2093864
Ki 7.27 7.27 53.6 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
2887657 10.1021/jm00392a005 Adrenergic receptor alpha-2 2
2887657 10.1021/jm00392a005 Mus musculus 1

Data from ChEMBL 36 via Core Engine