Assay Detail
Functional
CHEMBL1033248
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Antiproliferative activity against human HL-60 cells after 72 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, mechanistic studies, and anti-proliferative activity of glutathione/glutathione S-transferase-activated nitric oxide prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.05 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL455983 | — | — | 1 | 6.70 |
| CHEMBL212378 | — | — | 1 | 6.70 |
| CHEMBL512379 | — | — | 1 | 6.70 |
| CHEMBL455984 | — | — | 1 | 5.96 |
| CHEMBL515670 | — | — | 1 | 5.85 |
| CHEMBL456191 | — | — | 1 | 5.75 |
| CHEMBL458504 | — | — | 1 | 5.42 |
| CHEMBL446313 | — | — | 1 | 5.33 |
| CHEMBL457236 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL455983 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL212378 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL512379 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL455984 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL515670 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL456191 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL458504 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL446313 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL457236 | — | IC50 | > | 100000.0 | nM | - |